Modern vertical take-off and landing vehicles (VTOLs) could significantly affect the future of mobility. The broad range of their application fields encompasses urban air mobility, transportation and logistics as well as reconnaissance and observation missions in a military context. This article presents an efficient numerical framework for dynamic scheduling of multiple VTOLs. It combines a scheduling problem with optimal trajectory planning. The whole setting is formulated as a mixedinteger bilevel optimization problem. At the upper level, VTOLs are scheduled, and their starting times are computed. The solution of the lower level problem involves the computation of a value function and yields optimal trajectories for every aerial vehicle. In order to solve the bilevel problem, it is recast into a single-level one. The resulting mixed-integer nonlinear program (MINLP) is then piecewise linearized and solved numerically by a linear solver based on the Branch-and-Bound algorithm. Numerical results prove the feasibility of the approach proposed in this work.Keywords Bilevel optimization problem • dynamic scheduling of VTOLs • mixed-integer problem • piecewise linearization • shortest path • value function.