A novel molecularly imprinted polymer on CdSe/ZnS quantum dots for highly selective optosensing of mycotoxin zearalenone in cereal samples

Fang, Guozhen; Fan, Chao; Liu, Huilin; Pan, Mingfei; Zhu, Huidan; Wang, Shuo

doi:10.1039/c3ra45172k

Cited by 47 publications

(21 citation statements)

References 42 publications

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“…Taking into account the advantages of this approach, mimetic cyclododecyl ester of 2,4-dihydroxybenzoic acid (CDHB) ( Figure 2) was used as a dummy template for the MIP membranes' synthesis, since it has been shown to be effective for the formation of zearalenone-selective sites in molecularly imprinted polymeric particles [13]. CDHB was synthesized using the modification of previously reported methods [13,36]. Cyclododecyl fragment of CDHB closely resembles the lactone macrocycle of zearalenone molecule, while dihydroxybenzoic fragment is common for zearalenone and its mimic.…”

Section: Synthesis Of a Zearalenone Mimic Cyclododecyl Ester Of 24-dmentioning

confidence: 99%

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sergeyeva

Yarynka

Dubey

et al. 2020

Sensors

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The combination of the generic mobile technology and inherent stability, versatility and cost-effectiveness of the synthetic receptors allows producing optical sensors for potentially any analyte of interest, and, therefore, to qualify as a platform technology for a fast routine analysis of a large number of contaminated samples. To support this statement, we present here a novel miniature sensor based on a combination of molecularly imprinted polymer (MIP) membranes and a smartphone, which could be used for the point-of-care detection of an important food contaminant, oestrogen-like toxin zearalenone associated with Fusarium contamination of cereals. The detection is based on registration of natural fluorescence of zearalenone using a digital smartphone camera after it binds to the sensor recognition element. The recorded image is further processed using a mobile application. It shows here a first example of the zearalenone-specific MIP membranes synthesised in situ using “dummy template”-based approach with cyclododecyl 2, 4-dihydroxybenzoate as the template and 1-allylpiperazine as a functional monomer. The novel smartphone sensor system based on optimized MIP membranes provides zearalenone detection in cereal samples within the range of 1–10 µg mL−1 demonstrating a detection limit of 1 µg mL−1 in a direct sensing mode. In order to reach the level of sensitivity required for practical application, a competitive sensing mode is also developed. It is based on application of a highly-fluorescent structural analogue of zearalenone (2-[(pyrene-l-carbonyl) amino]ethyl 2,4-dihydroxybenzoate) which is capable to compete with the target mycotoxin for the binding to zearalenone-selective sites in the membrane’s structure. The competitive mode increases 100 times the sensor’s sensitivity and allows detecting zearalenone at 10 ng mL−1. The linear dynamic range in this case comprised 10–100 ng mL−1. The sensor system is tested and found effective for zearalenone detection in maize, wheat and rye flour samples both spiked and naturally contaminated. The developed MIP membrane-based smartphone sensor system is an example of a novel, inexpensive tool for food quality analysis, which is portable and can be used for the “field” measurements and easily translated into the practice.

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Section: Synthesis Of a Zearalenone Mimic Cyclododecyl Ester Of 24-dmentioning

confidence: 99%

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sergeyeva

Yarynka

Dubey

et al. 2020

Sensors

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“…Surface-enhanced Raman Spectroscopy (SERS) is another tool that has been used as an optical transducer for the direct detection of target-MIP rebinding at solid-liquid interfaces [ 193 , 194 ]. SERS is particularly interesting because of its ultra-sensitive detection mechanism that allows for the detection of analytes in the femtomolar range [ 195 ]. Interesting applications using SERS-based sensors have been developed in recent years mainly focusing on food safety and environmental monitoring [ [196] , [197] , [198] , [199] ].…”

Section: Mips As Receptors In Sensing Devicesmentioning

confidence: 99%

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

183

103

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Highlights The review aims to summarize recent commercially interesting innovations in MIP-based sensor design. In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed. The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems. The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.

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“…This MIP sensor was successfully applied in cereals and human serum samples [ 51 ]. Based on the ionic liquid-stabilized CdSe/ZnS QDs, Fang et al established a molecularly imprinted optosensing material (MIOM) for ZEN detection in the fluorescence sensors [ 73 ]. During the polymerization of MIOM, CDHB was used as the template molecules, and the modified CdSe/ZnS QDs were bound to the polymers as the fluorescent labels.…”

Section: Biosensors Chemosensors and Assays Based On Novel Recognmentioning

confidence: 99%

“…With the addition and binding of different concentration ZEN, the fluorescence intensity of MIOM would be accordingly quenched, and detected by spectrofluorometry. This MIOM of ZEN showed high recoveries for corn, rice and wheat flour samples [ 73 ].…”

Section: Biosensors Chemosensors and Assays Based On Novel Recognmentioning

confidence: 99%

Advances in Biosensors, Chemosensors and Assays for the Determination of Fusarium Mycotoxins

Lin

Guo

2016

Toxins

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The contaminations of Fusarium mycotoxins in grains and related products, and the exposure in human body are considerable concerns in food safety and human health worldwide. The common Fusarium mycotoxins include fumonisins, T-2 toxin, deoxynivalenol and zearalenone. For this reason, simple, fast and sensitive analytical techniques are particularly important for the screening and determination of Fusarium mycotoxins. In this review, we outlined the related advances in biosensors, chemosensors and assays based on the classical and novel recognition elements such as antibodies, aptamers and molecularly imprinted polymers. Application to food/feed commodities, limit and time of detection were also discussed.

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A novel molecularly imprinted polymer on CdSe/ZnS quantum dots for highly selective optosensing of mycotoxin zearalenone in cereal samples

Cited by 47 publications

References 42 publications

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Advances in Biosensors, Chemosensors and Assays for the Determination of Fusarium Mycotoxins

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