A novel multi-stimuli-responsive theranostic nanomedicine based on Fe3O4@Au nanoparticles against cancer

Massoumi, Bakhshali; Farnudiyan‐Habibi, Amir; Derakhshankhah, Hossein; Samadian, Hadi; Jahanban‐Esfahlan, Rana; Jaymand, Mehdi

doi:10.1080/03639045.2020.1821052

Cited by 18 publications

(4 citation statements)

References 41 publications

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“…4 . The XRD pattern of the pristine MNPs displayed some peaks at 2θ diffraction values of 2θ = 30.5°, 36.0°, 43.2°, 52.8°, 57.9°, and 63.0° conforming the (220), (311), (400), (422), (511) and (440) prisms of Fe 3 O 4 crystalline structure, respectively [ 59 ]. As seen, the pure β-CD has crystalline structure (in polyhedral form).…”

Section: Resultsmentioning

confidence: 99%

Thermal-responsive β-cyclodextrin-based magnetic hydrogel as a de novo nanomedicine for chemo/hyperthermia treatment of cancerous cells

Eskandani,

Jahanban-Esfahlan,

Sadughi

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Thermal-responsive β-cyclodextrin-based magnetic hydrogel as a de novo nanomedicine for chemo/hyperthermia treatment of cancerous cells

Eskandani,

Jahanban-Esfahlan,

Sadughi

et al. 2024

Heliyon

Self Cite

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“…In another study, Fe 3 O 4 @Au nanoparticles were conjugated with a thiol end-capped poly(Nisopropylacrylamide-block-acrylic acid) (HS-PNIPAAm-b-PAA) and subsequently loaded with DOX drug to form a theranostic nanomedicine. [178] The polymer bore pH and thermal responsivity properties. In vitro drug release studies were conducted [160] Copyright 2012, American Chemical Society.…”

Section: Stimulus-responsive Iron-based Nanoparticle Contrast Agentsmentioning

confidence: 99%

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

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Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

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“…Massoumi et al provided novel multi-stimuli-responsive theranostic nanomedicines that were configured and manufactured by combining a thiol end-capped poly (N-isopropyl acrylamide-block-acrylic acid) (HS-PNIPAAm-b-PAA) onto Fe 3 O 4 @Au nanostructures and achieved physical loading of doxorubicin (DOX) as a common anticancer drug. They formed Fe 3 O 4 @AuNPs via a short Au nanolayer grown on larger magnetic NPs [ 23 ]. Similarly, Mingliang Pei et al explored the cellular uptake of the DOX@β-CD-CQD theranostic agent by microphotography [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications

Esmaeilpour

Broscheit

Shityakov

2022

IJMS

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Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.

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A novel multi-stimuli-responsive theranostic nanomedicine based on Fe₃O₄@Au nanoparticles against cancer

Cited by 18 publications

References 41 publications

Thermal-responsive β-cyclodextrin-based magnetic hydrogel as a de novo nanomedicine for chemo/hyperthermia treatment of cancerous cells

Thermal-responsive β-cyclodextrin-based magnetic hydrogel as a de novo nanomedicine for chemo/hyperthermia treatment of cancerous cells

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications

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