Facing the pressure of low-cost competition brought by the homogenization of commodities, the manufacturing industry seeks to survive by providing services. By providing outsourcing of value-added services to date, we are focusing on innovation in our business model. With the advancement of science and technology, manufacturing innovation is facing higher challenges, especially the popularization of the Internet, which makes the manufacturing industry have to move closer to new industries. Based on cloud computing, this paper conducts a multiagent simulation on the evolution factors of the innovation network of advanced manufacturing. This article takes three types of simulation subjects: evolutionary network, manufacturing (cluster), and innovation evolution system as the research objects. The factors affecting the evolution of the research are innovation resources, innovation opportunities, innovation desire, innovation pressure, relationship strength, network scale, and network scope. Network differences carry over variable indicators and analyze quantitative regression indicators and then build a research model. The research results show that the average conversion efficiency of the manufacturing industry (0.523) is significantly lower than the average R&D innovation efficiency (0.725), which to a certain extent indicates that the manufacturing industry still has weak links in the export conversion stage at the back end of the innovation value chain. Some of the companies may have problems such as low ability to transform scientific and technological achievements and insufficient export competitiveness of high-tech products, which to a large extent affects and restricts the improvement of manufacturing export transformation efficiency.