A novel multiple linear multivariate NIR calibration model‐based strategy for in‐line monitoring of continuous mixing

Abstract

The capability of near infra-red (NIR) spectroscopy to predict many different variables, such as concentration and humidity, has been demonstrated in many published works. Several of those articles have been in the subject of real time prediction of continuous operations. However, those demonstrations have been for narrow ranges of the variables, especially for powder concentration, which could present a nonlinear behavior of the NIR absorbance as a function of the entire range of concentration. This work developed a novel strategy to predict the entire range of powder concentration using multiple linear NIR calibration models. The root mean standard error of prediction and relative standard deviation (RSD) parameters were used to establish the number of the multiple linear calibration models; other statistical features were used to establish the correct prediction. It was found that a minimum number of linear partial least squares (PLS) calibration models were necessary to accurately predict the range from 0 to 100% w/w. This technique could also be used with other nonlinear behaviors.

Simulation of a Compressible Powder Flow under Oscillatory Shear Stress Modeled as a Non - Linear Fluid by Using an Explicit Solution Method

“…When it is produced a drug in a pharmaceutical industry, it is well known that small changes in the properties of the ingredients or in the operating conditions of a process can cause a negative impact on its quality, leading to dangerous and expensive consequences. The fact that just a small change in the operating parameters can result in a final product with unpredictable physicochemical properties, has provoked the use of exhaustive monitoring systems in pharmaceutical companies in order to control and make the product quality as efficient as possible [2]. Therefore, the understanding of the physical phenomena that govern the flow and the mixing process of the ingredients that participate in the production of medicines is extremely important to guarantee their quality and to minimize health risks [3].…”

NIR-Based Simultaneous Measurement of Amine Loading and Degree of Neutralization during Flotation Reagent Preparation for Potash Processing

“…High degrees of precision have been achieved in terms of monitoring pH, amine solutions, and hydrocarbon concentrations [6][7][8][9][10][11]. The use of in-line monitoring throughout continuous mixing of solution has been established in several studies [12]. Given that the FT-NIR can monitor the homogeneity of a solution, [13][14][15][16] it provides the means for testing out the homogeneity of solutions during mixing by in-line monitoring [12,16].…”

“…The use of in-line monitoring throughout continuous mixing of solution has been established in several studies [12]. Given that the FT-NIR can monitor the homogeneity of a solution, [13][14][15][16] it provides the means for testing out the homogeneity of solutions during mixing by in-line monitoring [12,16]. The Antaris II FT-NIR analyzer will be utilized to monitor both amine weight percent and DON in a mini-fluidic system specifically configured for continuous production partially and fully neutralized solutions.…”