2018
DOI: 10.1152/jn.00012.2018
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A novel mutual information estimator to measure spike train correlations in a model thalamocortical network

Abstract: The impact of thalamic state on information transmission to the cortex remains poorly understood. This limitation exists due to the rich dynamics displayed by thalamocortical networks and because of inadequate tools to characterize those dynamics. Here, we introduce a novel estimator of mutual information and use it to determine the impact of a computational model of thalamic state on information transmission. Using several criteria, this novel estimator, which uses an adaptive partition, is shown to be superi… Show more

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Cited by 17 publications
(14 citation statements)
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“…The effects were stronger in the MGB than the AC, further suggesting that the MGB serves as a relay for cortico-collicular control. These effects could be accounted for by a three-cell model of the TRN-MGB-AC connections ( Figures 3A and 4), with the critical effect provided by the difference in timing and magnitude of the inhibition that the TRN delivered to the MGB, consistent with previous thalamocortical models (Gribkova et al, 2018;Haas and Landisman, 2012;Pham and Haas, 2018;Willis et al, 2015). Our study thus establishes an important pathway connecting the emotional and sensory processing centers that potentially drives changes in auditory perception as a result of emotional learning.…”
Section: Discussionsupporting
confidence: 86%
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“…The effects were stronger in the MGB than the AC, further suggesting that the MGB serves as a relay for cortico-collicular control. These effects could be accounted for by a three-cell model of the TRN-MGB-AC connections ( Figures 3A and 4), with the critical effect provided by the difference in timing and magnitude of the inhibition that the TRN delivered to the MGB, consistent with previous thalamocortical models (Gribkova et al, 2018;Haas and Landisman, 2012;Pham and Haas, 2018;Willis et al, 2015). Our study thus establishes an important pathway connecting the emotional and sensory processing centers that potentially drives changes in auditory perception as a result of emotional learning.…”
Section: Discussionsupporting
confidence: 86%
“…We constructed a three-cell model of MGB, TRN, and AC neurons ( Figure 4). As all thalamic neurons exhibit bursts of spikes resulting from T currents (Gribkova et al, 2018;Huguenard, 1996;Willis et al, 2015), we used a bursting neuron model for our TRN and MGB neurons (Haas and Landisman, 2012;Traub et al, 2005a). Our simulation code is available at https://github.com/jhaaslab/ trn_aud.…”
Section: Photo-activation Of the Bla-trn Pathway Increases The Amplitmentioning
confidence: 99%
“…6 C,D). Using the MI estimator AIMIE 37 , we show that there is a greater degree of similarity between the original signal and recall signal reconstructed from SITDL simulations (Fig. 6 E).…”
Section: Resultsmentioning
confidence: 91%
“…A mutual information (MI) estimator (Adaptive partition using Interspike intervals MI Estimator (AIMIE)), was used to compare recall signal and original glutamate signal 37 . Short signals were repeated with proper periodicity, such that each signal had at least 4000 spikes for more accurate MI estimation.…”
Section: Methodsmentioning
confidence: 99%
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