A novel N-alkylation of amines by alkyl halides on mixed oxides at room temperature

Role of mixed metal oxides in catalysis science—versatile applications in organic synthesis

“…The Al 2 O 3 -OK was prepared by a simple impregnation method and the synthesized Al 2 O 3 -OK catalyst was characterized by XRD, SEM-EDS, elemental analysis, particle size analysis, BET surface area, pore size and average pore diameter. 26 In order to know about the homogeneity of Al 2 O 3 -OK, SEM analysis was carried out. It has been noted that the K 2 O base was finely and uniformly distributed over the Al 2 O 3 support, which makes the catalyst more active (Fig.…”

Selective N-Alkylation of Amines with DMC over Biogenic Cu–Zr Bimetallic Nanoparticles

“…Alkylamines are often prepared by carrying alkylation of lower amines with alkyl halides 5 or dimethyl sulfate. 6 These reagents, apart from being toxic, also lead to the generation of stoichiometric amounts of halides and sulfate wastes ( Scheme 1 ).…”

Mechanisms of water-promoted aryl azide conversion into N-alkylated aniline: Two competitive pathways

“…[4,5] In the past decades, many methods have been developed for the synthesis of N-alkylated amines, including the employments of alcohols, alkylbromide, [31,32] nitriles, [33,34] aldehydes, [1] alkyl halides, [35][36][37][38][39] allyl and benzyl halides, [36,39] R-NH 2 ·HBr and alkyl bromides, [40] carboxylic acids [41] and dialkylboron triflates. [42] In recent years, organic azides have been considered to be valuable intermediates in the synthesis of N-alkylated anilines in spite of their explosive features.…”