A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity

Abstract

The pincer ligand 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (bpmt) was used to synthesize the novel [Na(bpmt)2][AuCl4] complex through the self-assembly method. In this complex, the Na(I) ion is hexa-coordinated with two tridentate N-pincer ligands (bpmt). The two bpmt ligand units are meridionally coordinated to Na(I) via one short Na-N(s-triazine) and two slightly longer Na-N(pyrazole) bonds, resulting in a distorted octahedral geometry around the Na(I) ion. In the coordinated bpmt ligand, the s-triazine core is not found to be coplanar with the two pyrazole moieties. Additionally, the two bpmt units are strongly twisted from one another by 64.94°. Based on Hirshfeld investigations, the H···H (53.4%) interactions have a significant role in controlling the supramolecular arrangement of the [Na(bpmt)2][AuCl4] complex. In addition, the Cl···H (12.2%), C···H (11.5%), N···H (9.3%), and O···H (4.9%) interactions are significant. Antimicrobial investigations revealed that the [Na(bpmt)2][AuCl4] complex has promising antibacterial and antifungal activities. The [Na(bpmt)2][AuCl4] complex showed enhanced antibacterial activity for the majority of the studied gram-positive and gram-negative bacteria compared to the free bpmt (MIC = 62.5–125 µg/mL vs. MIC = 62.5–500 µg/mL, respectively) and Amoxicillin (MIC > 500 µg/mL) as a positive control. Additionally, the [Na(bpmt)2][AuCl4] complex had better antifungal efficacy (MIC = 125 µg/mL) against C. albicans compared to bpmt (MIC = 500 µg/mL).

A New Zn(II) Azido Complex of L-Arginine: X-ray Crystal Structure, Hirshfeld, and AIM Studies

“…Over the past ten years, there has been a lot of interest in the self-assembly of supramolecular structures involving metal coordination compounds because of their potential uses in many domains such as catalysis [1][2][3] and biological systems [4]. In coordination chemistry, multi-dentate ligands play a significant role because they can form metal complexes with extra stability as a result of the chelate effect [5][6][7][8][9][10][11]. First row transition metals have a variety of coordination numbers and can be used to bind ligands to create coordination complexes with diverse of coordination geometries [12][13][14][15][16].…”

Synthesis, Crystal Structure Analyses, and Antibacterial Evaluation of the Cobalt(II) Complex with Sulfadiazine-Pyrazole Prodrug

“…Recently, the application of metal complexes in medicine, especially in cancer therapy [16][17][18], bacterial infection treatment [19,20], and as antifungal agents [21,22], has attracted widespread interest. In particular, metal complexes of sulfadiazine have drawn much attention by many researchers [23][24][25][26].…”

Synthesis, X-ray Structure, and Hirshfeld Analysis of [Ag(3-amino-5,6-dimethyl-1,2,4-triazine)(NO3)]n: A Potent Anticancer and Antimicrobial Agent

“…Drugs with 1,2,4-triazine moiety were found in many synthetic and natural products, such as lamotrigine and azaribine, which have significant pharmacological effects [29]. Also, there are several examples of biologically active complexes with triazine ligands [30][31][32][33][34]. Previous studies [35,36] showed that the addition of planar-condensed aromatic ligands containing nitrogen (whose donor characteristics are similar to those of pyrimidine and purine bases) to anti-tumor agents leads to intriguing features that can be used to create new drugs.…”