A novel nanocomposite film prepared from crosslinked cellulosic whiskers

Bone regeneration is a coordinated process mainly regulated by multiple growth factors. Vascular endothelial growth factor (VEGF) stimulates angiogenesis and bone morphogenetic proteins (BMPs) induce osteogenesis during bone healing process. The aim of this study was to investigate how these growth factors released locally and sustainably from nano-cellulose (NC) simultaneously effect bone formation. A biphasic calcium phosphate (BCP)-NC-BMP2-VEGF (BNBV) scaffold was fabricated for this purpose. The sponge BCP scaffold was prepared by replica method and then loaded with 0.5% NC containing BMP2-VEGF. Growth factors were released from NC in a sustainable manner from 1 to 30 days. BNBV scaffolds showed higher cell attachment and proliferation behavior than the other scaffolds loaded with single growth factors. Bare BCP scaffolds and BNBV scaffolds seeded with rat bone marrow mesenchymal stem cells were implanted ectopically and orthotopically in nude mice for 4 weeks. No typical bone formation was exhibited in BNBV scaffolds in ectopic sites. BMP2 and VEGF showed positive effects on new bone formation in BNBV scaffolds, with and without seeded stem cells, in the orthotopic defects. This study demonstrated that the BNBV scaffold could be beneficial for improved bone regeneration. Stem cell incorporation into this scaffold could further enhance the bone healing process.

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“…15,46,52 The release behavior obtained from this study was suitable for large defect bone regeneration process, which needs at least 1 month.…”

Section: Discussionmentioning

confidence: 99%

Effect of Local Sustainable Release of BMP2-VEGF from Nano-Cellulose Loaded in Sponge Biphasic Calcium Phosphate on Bone Regeneration

Sukul

Linh

Min

et al. 2015

Tissue Engineering Part A

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“…Cellulose is the most abundant natural biopolymer found in the world, and it has considerable advantages, such as environmental friendliness, biodegradability, and renewability (Goetz et al 2009;Li et al 2009;Zuluaga et al 2009). Many different kinds of cellulose materials exist in nano-scale.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Polysulfone/Sulfonated Polysulfone/Cellulose Nanofibers Ternary Blend Membranes

Zhong¹,

Ding²,

Li³

et al. 2015

BioResources

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Ternary blend membranes were prepared with polysulfone (PSf), sulfonated polysulfone (SPSf), and cellulose nanofibers (CNF) by a LoebSourirajan (L-S) phase inversion process. The cross-section and bottom surface morphology of the membranes were analyzed by scanning electron microscopy (SEM), and the performance of the membranes was evaluated in terms of pure water flux, bovine serum albumin (BSA) rejection, contact angle, tensile strength, and breaking elongation. The morphology of the cellulose nanofibers (CNF) was detected by transmission electron microscopy (TEM). Results showed that within a certain range, the addition of SPSf improved compatibility between PSf and CNF, and the addition of CNF could improve the hydrophilicity of the membranes. The maximum value of pure water flux reached 137.6 L/m 2 h, and the minimum value of BSA rejection reached 95.8% when CNF content was 0.3 wt% in casting solution. Also, a certain addition of CNF could enhance the mechanical properties of the membranes.

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“…Neste sentido, Goetz e colaboradores 173 prepararam um compósito com poli(metil-vinil-éter-co-ácido malêico), poli(etileno glicol) e nanocristais de celulose. A formação de grupos ésteres entre a matriz polimérica e os nanocristais de celulose aumenta a interação entre os componentes do compósito, possibilitando a adição de maiores teores de nanocristais de celulose.…”

Section: Nanocompósitos Com Nanocristais De Celuloseunclassified

Aplicações de fibras lignocelulósicas na química de polímeros e em compósitos

2009

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Recebido em 19/1/09; aceito em 25/3/09; publicado na web em 2/4/09 APPLICATIONS OF LIGNOCELLULOSIC FIBERS IN POLYMER CHEMISTRY AND IN COMPOSITES. The use of lignocellulosic fibers and their constituents, as raw materials in the production of polymeric and composite materials, represent an exceptional opportunity of sustainable technological development. In the present report works that discuss promising alternatives of obtaining and use of materials such as cellulose, hemicellulose, lignin, cellulose nanocrystals and biocomposites were revised. The advance in the use of biomass can be, in a near future, capable of going beyond the application difficulties of these vast materials, especially in relation to the economical unviability, by the production of high performance polymeric and composite materials. This advance would represent a higher profitability to some areas of agrobusiness, especially the sector of biofuels, which produces elevated amounts of biomass waste.Keywords: lignocellulosic fibers; nanowhiskers; biocomposites. introduçÃoNos últimos anos tem surgido um grande interesse mundial no desenvolvimento de tecnologias "verdes" que possibilitem a utilização de produtos de menor impacto ambiental.1-4 A química "verde", como um todo, implica no desenvolvimento de processos químicos e produtos que levem a um ambiente mais limpo, saudável e sustentável. Neste contexto, os materiais plásticos sintéticos têm recebido especial atenção por conter em seus métodos de preparação questões que devem ser priorizadas. As questões que devem ser priorizadas são a não-biodegradabilidade dos plásticos sintéticos e por serem oriundos de fontes não-renováveis. 5-8Na busca pela sustentabilidade, várias pesquisas e trabalhos na área de materiais poliméricos e compósitos foram, e estão sendo, realizados para garantir a preservação ambiental e proporcionar um melhor padrão de vida à sociedade.9-13 Dentre as pesquisas nesta área, as que buscam a aplicação de recursos naturais na preparação dos materiais vêm crescendo, podendo-se destacar o uso de fibras naturais. [14][15][16][17][18][19][20][21][22] A Organização das Nações Unidas para a Agricultura e a Alimentação (FAO-ONU -Food and Agriculture Organization of the United Nations) declarou o ano de 2009 como o ano internacional das fibras naturais.23 A medida visa conscientizar e estimular a utilização de fibras naturais, encorajando políticas governamentais de incentivo ao setor e às ações empresariais sustentáveis, para a exploração dessas matérias-primas.Destaque ainda maior deve ser dado à utilização de fibras naturais de origem vegetal, em razão da enorme variedade de espécies passí-veis de serem pesquisadas. Diversas fibras vegetais são produzidas em praticamente todos os países e usualmente são designadas como materiais lignocelulósicos. Algumas fibras ocorrem espontaneamente na natureza, outras são cultivadas como atividade agrícola e ainda há aquelas que são resíduos gerados, principalmente, pela agroindústria. Na Tabela 1 pode ser verificada a produção anual das princ...

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A novel nanocomposite film prepared from crosslinked cellulosic whiskers

Cited by 127 publications

References 25 publications

Effect of Local Sustainable Release of BMP2-VEGF from Nano-Cellulose Loaded in Sponge Biphasic Calcium Phosphate on Bone Regeneration

Effect of Local Sustainable Release of BMP2-VEGF from Nano-Cellulose Loaded in Sponge Biphasic Calcium Phosphate on Bone Regeneration

Preparation and Characterization of Polysulfone/Sulfonated Polysulfone/Cellulose Nanofibers Ternary Blend Membranes

Aplicações de fibras lignocelulósicas na química de polímeros e em compósitos

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