A novel near-infrared polymethine dye biosensor for rapid and selective detection of lithocholic acid

Zheng, Jianlu; Zhang, Wencui; Gong, Yanli; Liang, Wenlang; Leng, Yongxiang

doi:10.1016/j.bios.2024.116383

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2024.116383

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A novel near-infrared polymethine dye biosensor for rapid and selective detection of lithocholic acid

Jianlu Zheng,

Wencui Zhang,

Yanli Gong

et al.

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Cited by 2 publications

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The bile acid profile

Liu,

You

2025

Clinica Chimica Acta

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The bile acid profile

Liu,

You

2025

Clinica Chimica Acta

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A Highly Sensitive and Rapid Enzyme Biosensor Based on AuNPs/CS@cMWCNTS for Detecting Fusarium Acid

Dang,

Sun,

Shi

et al. 2024

J. Electrochem. Soc.

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Fusarium acid (FSA) serves as a highly sensitive biomarker for the early warning of bulb rot in Lanzhou lily caused by Fusarium oxysporum infection. Realizing its highly sensitive, accurate, and rapid detection is crucial for the early warning and control of lily bulb rot. Herein, an enzyme biosensor based on the enzyme inhibition principle was developed for the rapid detection of FSA. Firstly, chitosan-functionalized carboxylated multi-walled carbon nanotubes and gold nanoparticles were modified on a bare electrode by drop coating and electrochemical deposition methods, respectively. Subsequently, dopamine β-hydroxylase (DBH) was firmly immobilized on the electrode surface through the gold-sulfur bond. Because the activity of DBH can be inhibited by FSA, which leads to a noticeable change in the signal response during the conversion of dopamine (DA) to norepinephrine (NA). Under optimized experimental conditions, the sensor exhibits an excellent linear relationship in the concentration range of 1.00 × 10-5 μg mL-1 ~ 1.00 ×103 μg mL-1 with the correlation coefficient of 0.9856 and the detection limit is 4.60 pg mL-1. This method enables the highly sensitive and rapid detection of FSA in real samples, and provides scientific basis and technical support for early warning of diseases.

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A novel near-infrared polymethine dye biosensor for rapid and selective detection of lithocholic acid

Cited by 2 publications

References 56 publications

The bile acid profile

The bile acid profile

A Highly Sensitive and Rapid Enzyme Biosensor Based on AuNPs/CS@cMWCNTS for Detecting Fusarium Acid

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