A novel near-infrared trifluoromethyl heptamethine cyanine dye with mitochondria-targeting for integration of collaborative treatment of photothermal and sonodynamic therapy

Shi, Haoran; Tan, Xuecai; Wang, Ping; Qin, Jieling

doi:10.1016/j.mtadv.2022.100251

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Cyanine dye studies are nowadays widely focused on biological and medicinal research. New potential uses for cyanine dyes are for example cancer treatment [1][2][3], nanofibers mimicking tissues [4], detecting cysteine, which is linked to many illnesses, such as Alzheimer's disease [5], turn-on probes for redox reactions in cells [6] and using cyanine dyes as selective fluorescent probes for RNA [7]. Cyanine dyes are already a popular choice as fluorescent probes to image nucleic acids in many cell and molecular biology laboratories [8].…”

Section: Introductionmentioning

confidence: 99%

Optimizing the SYBR green related cyanine dye structure to aim for brighter nucleic acid visualization

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Optimizing the SYBR green related cyanine dye structure to aim for brighter nucleic acid visualization

et al. 2023

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“…However, for benz[ e ]indole-based brominated Cy5, the same research group shows that there is no advantage in these halogenated ones compared to non-halogenated ones, indicating that the heterocycle may play a role [ 265 ]. Intending to improve its bioavailability, Shi et al introduce the trifluoromethyl group into the Cy7 N -alkyl chains, stating that this structural modification can improve the cellular uptake of the dye [ 266 ].…”

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Lima

Reis

2023

Molecules

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Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy that generally results from the simultaneous action of three factors: a molecule with high sensitivity to light, the photosensitizer, molecular oxygen in the triplet state, and light energy. There is much to be said about each of these three elements; however, the efficacy of the photosensitizer is the most determining factor for the success of this therapeutic modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, and cyanines are some of the N-heterocycle-bearing dyes’ classes with high biological promise. In this review, a concise approach is taken to these and other families of potential photosensitizers and the molecular modifications that have recently appeared in the literature within the scope of their photodynamic application, as well as how these compounds and their formulations may eventually overcome the deficiencies of the molecules currently clinically used and revolutionize the therapies to eradicate or delay the growth of tumor cells.

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“…First, they are directly used in tumor phototherapy including PDT which relies on NIR light to produce ROS to induce tumor cell apoptosis, and PTT, which relies on photothermal agents to absorb NIR light and generate heat and lead to overheating and induce tumor cell apoptosis. similarly, they are also used in sonodynamic therapy (SDT) that relies on ultrasonic stimulation to produce ROS (Shi et al, 2022). In addition, chemotherapy, radiotherapy, and immunotherapy drugs are used in combination with heptamethine cyanine dyes to enhance the therapeutic effect of these traditional therapies.…”

Section: Heptamethine Cyanine Dye-based Photoacoustic Imagingmentioning

confidence: 99%

Recent progress on near‐infrared fluorescence heptamethine cyanine dye‐based molecules and nanoparticles for tumor imaging and treatment

Qiu

Yuan

Cao

et al. 2023

WIREs Nanomed Nanobiotechnol

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Recenly, near‐infrared fluorescence heptamethine cyanine dyes have shown satisfactory values in bioengineering, biology, and pharmacy especially in cancer diagnosis and treatment, owing to their excellent fluorescence property and biocompatibility. In order to achieve broad application prospects, diverse structures, and chemical properties of heptamethine cyanine dyes have been designed to develop novel functional molecules and nanoparticles over the past decade. For fluorescence and photoacoustic tumor imaging properties, heptamethine cyanine dyes are equipped with good photothermal performance and reactive oxygen species production properties under near‐infrared light irradiation, thus holding great promise in photodynamic and/or photothermal cancer therapies. This review offers a comprehensive scope of the structures, comparisons, and applications of heptamethine cyanine dyes‐based molecules as well as nanoparticles in tumor treatment and imaging in current years. Therefore, this review may drive the development and innovation of heptamethine cyanine dyes, significantly offering opportunities for improving tumor imaging and treatment in a precise noninvasive manner.This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

A novel near-infrared trifluoromethyl heptamethine cyanine dye with mitochondria-targeting for integration of collaborative treatment of photothermal and sonodynamic therapy

Cited by 9 publications

References 44 publications

Optimizing the SYBR green related cyanine dye structure to aim for brighter nucleic acid visualization

Optimizing the SYBR green related cyanine dye structure to aim for brighter nucleic acid visualization

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Recent progress on near‐infrared fluorescence heptamethine cyanine dye‐based molecules and nanoparticles for tumor imaging and treatment

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