A novel near-infrared turn-on and ratiometric fluorescent probe capable of copper(<scp>ii</scp>) ion determination in living cells

Aydin, Ziya; Yan, Bing; Wei, Yibin; Guo, Maolin

doi:10.1039/d0cc01481h

Cited by 60 publications

(18 citation statements)

References 34 publications

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“…These findings were in line with previous mechanochromic polymers and indicated that the increase of the mechanically induced ring‐opened Rh‐Co moiety within the hydrogel network could essentially enhance the stress sensing properties. [ 40 ] In this sense, the Rh‐Co mechanophore provided a facile compress‐sensing platform.…”

Section: Resultsmentioning

confidence: 99%

A Chromic and Near‐Infrared Emissive Mechanophore Serving as a Versatile Force Meter in Micelle–Hydrogel Composites

Yang

Chen

2022

Advanced Optical Materials

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molecular details can be characterized in a visualized and quantitative way, not only will the alert of stress evolution and polymer failure be realized, but also fundamental insight in the molecular origins of toughness will be possible. [11][12][13] Over the past decade, polymer mechanochemistry has been recognized as a unique tool to bring about productive chemical reactions with a largely unexplored stimulusmechanical force, therefore is powerful in shedding light on how force is distributed within macromolecular structures. [14][15][16][17][18] Mechanofluorochromic hydrogels, which can indicate damage or excessive stress in highly polarized environments with a clearly perceptible optical signal, are potentially useful in a variety of biocompatible applications, such as bioimaging, stress sensor, optical storage, and biomechanics. [19][20][21][22][23][24][25] For this purpose, designing and engineering fluorochromic units ("mechanophores") in hydrogel networks have become the focus of research interest recently. For instance, typical mechanophores-spiropyran or rhodamine, when covalently incorporated into hydrogel networks constituting of the copolymer of methyl acrylate and acrylamide, could efficiently proceed color change during stretching. [26][27][28][29] The underlying mechanism is based on the opening of the spirocyclic ring to generate the colored and fluorescent isomers. Otsuka et al. demonstrated freezing-induced mechanoluminescence by introducing tetraarylsuccinonitrile moiety as the mechanochromophore at the cross-linking points of a polymer gel. [30][31][32] He et al. found Eu-containing hydrogels showed switchable on/off luminescence along with the force-dependent sol-gel transition through the reversible formation and dissociation of Eu-iminodiacetate complexes. [33] Despite these progresses, most reported mechano-responsive hydrogels displayed color-changing or emission in the visible wavelength region. Very recently, a near-infrared (NIR) mechanophore based on benzo[1,3]oxazine fused with a heptamethine cyanine moiety was developed. Its reversibility exhibited a strong polarity dependence. In polar solvent, irreversible mechanochemical transition was detected. Mechanophores featuring mechanochromism with high color contrast and penetrated NIR emission, as well as reversible mechanochemical switching in the aqueous environment are essential to fabricate NIR mechanochromic hydrogels for force mapping and in situ mechanics sensing, yet remains a great challenge. [34] Mechanofluorochromic polymers, which can indicate damage or excessive stress in highly polarized environments with a clearly perceptible optical signal, are potentially useful in a variety of exciting applications. However, most reported fluorochromic mechanophores exhibit poor color contrast and fluorescence penetration, or are irreversible in polarized phase after mechanical activation. Here, this challenge is tackled by designing and engineering a novel near-infrared (NIR) emissive, rhodanmin derived mechanophore (Rh-Co) in a kin...

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Section: Resultsmentioning

confidence: 99%

A Chromic and Near‐Infrared Emissive Mechanophore Serving as a Versatile Force Meter in Micelle–Hydrogel Composites

Yang

Chen

2022

Advanced Optical Materials

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“…[1][2][3] Excess accumulation of Cu 2+ in the body can lead to serious consequences, such as cellular damage, Menkes disease, Wilson disease, cancer, cardiovascular disorders, Alzheimer's disease and even death. [4][5][6] Therefore, maintaining Cu 2+ at appropriate concentrations is vital for the growth and tness of living organisms. Given the signicance of copper to human health, the selective and sensitive monitoring of Cu 2+ ions in living systems is of great importance to evaluate copperrelated diseases.…”

Section: Introductionmentioning

confidence: 99%

A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications

et al. 2022

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“…[18][19][20][21][22] However, some probes have a marked defect: the sensing mechanism is based on a fluorescence quenching effect, which limits the selectivity of the probe. [23][24][25] Other quenchers in real water samples may cause such 'on-off' signals, therefore, in the practical application process these fluorescence 'on-off' probes are unacceptable. Furthermore, most fluorescent probes for Cu 2+ have poor water solubility, low sensitivity, and poor selectivity.…”

Section: Introductionmentioning

confidence: 99%

Rhodol‐derived turn‐on fluorescent probe for copper ions with high selectivity and sensitivity

et al. 2021

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A new rhodol-derived fluorescent probe 1 with picolinate as the recognition receptor was designed and simply synthesized using a one-step reaction. With the concentration of added Cu 2+ increases, it gradually turns pink, so the effect of naked eye detection can be achieved. The detection limit of probe 1 for Cu 2+ is 42 nM, and the linear detection range was 0-2 μM. The experimental results showed that 1 was a fluorescent probe with high selectivity, good water solubility, and high sensitivity to Cu 2+ . Probe 1 was successfully applied in cell imaging experiments and can detect the concentration of Cu 2+ in water samples. All these indicate that probe 1 has the potential to be applied to the detection of Cu 2+ concentration in the real environment.

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A novel near-infrared turn-on and ratiometric fluorescent probe capable of copper(ii) ion determination in living cells

Abstract: A novel NIR ratiometric fluorescent probe has been developed for monitoring the dynamic changes of subcellular Cu2+ and quantifying its concentration at the nanomolar level in living cells.

Cited by 60 publications

References 34 publications

A Chromic and Near‐Infrared Emissive Mechanophore Serving as a Versatile Force Meter in Micelle–Hydrogel Composites

A Chromic and Near‐Infrared Emissive Mechanophore Serving as a Versatile Force Meter in Micelle–Hydrogel Composites

A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications

Rhodol‐derived turn‐on fluorescent probe for copper ions with high selectivity and sensitivity

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