A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease

Zhao, Yufang; Qiao, Shupei; Zhang, Bosong; Cao, Yue; Tian, Hui; Liu, Runze; Sun, Liuke; Cao, Wang Fang; Li, Liang; Wang, Ruiqi; Chen, Yue; Hou, Xiaolu; Li, Yongming; Zhou, Jin; Li, Liyi; Tian, Weiming

doi:10.1016/j.cej.2021.133090

Cited by 2 publications

(2 citation statements)

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“…Also, studies have demonstrated the good neuroinflammatory inhibitory effect of HA nanoparticles, thus improving cognitive impairment in mice. 20 , 52 IL‐1β plays a central role in the initiation and regulation of neuroinflammation and is the most significantly elevated inflammatory factor in neuroinflammation. 53 Also, COX‐2 has been reported to be an essential indicator for diagnosing AD.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, protecting polyphenols in vivo and delivery to the nervous system have been challenging and remain to be addressed. Our previous studies have demonstrated that hyaluronic acid (HA) has good neuroinflammation resistance, 20 as well as suitable biocompatibility in many biomedical applications. 21 , 22 , 23 , 24 , 25 , 26 , 27 Studies have shown that mitochondrial abnormalities are the leading cause of ROS accumulation in the nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease

Zhang

Zhao

Guo

et al. 2022

Bioengineering & Transla Med

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Prevention and early intervention are the current focus of treatment for Alzheimer's disease (AD). An increase in reactive oxygen species (ROS) is a feature of the early stages of AD, thus suggesting that the removal of excess ROS can be a viable method of improving AD. Natural polyphenols are able to scavenge ROS and thus promising for treating AD. However, some issues need to be addressed. Among them, important are that most polyphenols are hydrophobic, have low bioavailability in the body, are easily degraded, and that single polyphenols have insufficient antioxidant capacity. In this study, we employed two polyphenols, resveratrol (RES) and oligomeric proanthocyanidin (OPC), and creatively grafted them with hyaluronic acid (HA) to form nanoparticles to address the aforementioned issues. Meanwhile, we strategically grafted the nanoparticles with the B6 peptide, enabling the nanoparticles to cross the blood–brain barrier (BBB) and enter the brain for AD treatment. Our results illustrate that B6‐RES‐OPC‐HA nanoparticles can significantly scavenge ROS, reduce brain inflammation, and improve learning and memory ability in AD mice. B6‐RES‐OPC‐HA nanoparticles have the potential to prevent and alleviate early AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease

Zhang

Zhao

Guo

et al. 2022

Bioengineering & Transla Med

Self Cite

View full text Add to dashboard Cite

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Particle Hydrogels Decrease Cerebral Atrophy and Attenuate Astrocyte and Microglia/Macrophage Reactivity after Stroke

Sideris

Kioulaphides

Wilson

et al. 2022

Advanced Therapeutics

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Increasing numbers of individuals live with stroke related disabilities. Following stroke, highly reactive astrocytes and pro-inflammatory microglia can release cytokines and lead to a cytotoxic environment that causes further brain damage and prevents endogenous repair. Paradoxically, these same cells also activate pro-repair mechanisms that contribute to endogenous repair and brain plasticity. Here, it is shown that the direct injection of a hyaluronic acid-based microporous annealed particle (MAP) hydrogel into the stroke core in mice reduces the percent of highly reactive astrocytes, increases the percent of alternatively activated microglia, decreases cerebral atrophy, and preserves NF200 axonal bundles. Further, MAP hydrogel is shown to promote reparative astrocyte infiltration into the lesion, which directly coincides with axonal penetration into the lesion. This work shows that the injection of a porous scaffold into the stroke core can lead to clinically relevant decrease in cerebral atrophy and modulates astrocytes and microglia toward a pro-repair phenotype.

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A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease

Cited by 2 publications

References 54 publications

Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease

Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease

Particle Hydrogels Decrease Cerebral Atrophy and Attenuate Astrocyte and Microglia/Macrophage Reactivity after Stroke

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