A novel non-invasive brain stimulation technique: “Temporally interfering electrical stimulation”

Guo, Wanting; He, Yuchen; Zhang, Wenquan; Sun, Yangying; Wang, Junling; Liu, Shuang; Ming, Dong

doi:10.3389/fnins.2023.1092539

Cited by 18 publications

(12 citation statements)

References 76 publications

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“…However, the low-frequency interference field of the resulting beat frequency Δf has the potential to influence neuronal transmembrane potential (Bikson et al, 2004; Deans et al, 2007; Karimi et al, 2019). Therefore, TIS has recently drawn attention from researchers because it could offer new ways of modulating the neuronal systems and treating neurological conditions such as Parkinson’s disease and chronic pain (Grossman et al, 2018; Guo et al, 2023; Mirzakhalili et al, 2020; Opitz and Tyler, 2017; Rampersad et al, 2019; Song et al, 2021; Zhu and Yin, 2023). Thus far, TIS has been demonstrated using computational studies and in vivo applications with rodents (Carmona-Barrón et al, 2023; Grossman et al, 2017) and human subjects (Ma et al, 2022; Violante et al, 2023; Zhu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric Fields

Ahtiainen,

Leydolph,

Tanskanen

et al. 2023

Preprint

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SummaryA novel non-invasive electrical stimulation method, temporal interference stimulation (TIS), has been proposed to enable spatially steerable stimulation and to selectively activate different brain regions. However, TIS has not been studied with cell cultures that can provide an indepth assessment of its effects on neuronal cells. We successfully established anin vitroTIS setup using rat cortical neurons on microelectrode arrays. Stimulations involved 1) TIS with 653 Hz and 643 Hz, resulting in a 10 Hz frequency envelope, 2) low-frequency stimulation (LFS) at 10 Hz, 3) high-frequency stimulation (HFS) at 653 Hz, and 4) no electrical stimulation (control/sham). HFS and LFS had the least effect on neuronal activity, but TIS elicited neuronal electrophysiological responses, especially 24 hours after stimulation. We also assessed TIS in neuron-astrocyte co-cultures. Interestingly, co-cultures seemed to counteract the TIS effects. Hence, our findings deepen the current understanding of the electrical modulation of neurons during TIS.HighlightsTemporal interference stimulation (TIS) is a new technique for brain stimulation.TIS setup was established and combined with microelectrode array (MEA) system.Rat cortical neurons and astrocytes were stimulated with TISin vitro.Neurons responded to TIS more prominently without astrocyte support.

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Section: Introductionmentioning

confidence: 99%

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric Fields

Ahtiainen,

Leydolph,

Tanskanen

et al. 2023

Preprint

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“…TES is a non-invasive brain stimulation technique that involves applying low-intensity electrical currents to the scalp to modulate brain activity [49][50][51]. In recent years, several advances in TES technology have improved its effectiveness and expanded its potential applications.…”

Section: Recent Advances In Tes Technologymentioning

confidence: 99%

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Yen

Lin

Chiang

2023

Life

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Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used neuroimaging techniques to review changes in brain activity. fMRI is a noninvasive technique that uses magnetic fields and radio waves to produce detailed brain images. An EEG is a noninvasive technique that records the brain’s electrical activity through electrodes placed on the scalp. This review overviews recent developments in noninvasive functional neuroimaging methods, including fMRI and EEG. Recent advances in fMRI technology, its application to studying brain function, and the impact of neuroimaging techniques on neuroscience research are discussed. Advances in EEG technology and its applications to analyzing brain function and neural oscillations are also highlighted. In addition, advanced courses in neuroimaging, such as diffusion tensor imaging (DTI) and transcranial electrical stimulation (TES), are described, along with their role in studying brain connectivity, white matter tracts, and potential treatments for schizophrenia and chronic pain. Application. The review concludes by examining neuroimaging studies of neurodevelopmental and neurological disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). We also described the role of transcranial direct current stimulation (tDCS) in ASD, ADHD, AD, and PD. Neuroimaging techniques have significantly advanced our understanding of brain function and provided essential insights into neurological disorders. However, further research into noninvasive treatments such as EEG, MRI, and TES is necessary to continue to develop new diagnostic and therapeutic strategies for neurological disorders.

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“…Similarly, coils 2 and 5 were connected with continuous high-frequency stimulation signals, so there was no cortical response in this area. Selecting points 8 , 9 , and 10 to analyze the AM nx , the positions were (0, 30), (35,27), and (0, −45), respectively. The green, red, and blue lines in Figure 6C represent the induced electric field time-domain variation curves of points 8 , 9 , and 10 , respectively.…”

Section: Multi-target Temporal Interference Magnetic Stimulation In S...mentioning

confidence: 99%

“…Selecting points 8 , 9 , and 10 to analyze the AM nx , the positions were (0, 30), (35,27), and (0, −45), respectively. The green, red, and blue lines in Figure 6C represent the induced electric field time-domain variation curves of points 8 , 9 , and 10 , respectively. The results show that point 8 is located at the center of coils 1 and 2, so the AM nx was the largest; point 9 along the y-axis origin shifted 8 mm to the positive x direction, and the AM nx showed attenuation; point 10 AM nx was located outside the focus area, and the AM nx was the smallest, almost none.…”

Section: Multi-target Temporal Interference Magnetic Stimulation In S...mentioning

confidence: 99%

“…According to references [9][10][11][12][13][14][15], both temporal interference transcranial magnetic stimulation and temporal interference transcranial electrical stimulation are deep brain stimulation schemes based on the principle of temporal interference. Adjusting the spatial position of the coil can generate a low-frequency envelope-induced superimposed electric field in the target area, making neurons follow this low-frequency envelope oscillation to generate electrical activity.…”

Section: Introductionmentioning

confidence: 99%

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Optimal Design of Array Coils for Multi-Target Adjustable Electromagnetic Brain Stimulation System

Wang

Yang

et al. 2023

Bioengineering

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Temporal interference magnetic stimulation is a novel noninvasive deep brain neuromodulation technology that can solve the problem of balance between focus area and stimulation depth. However, at present, the stimulation target of this technology is relatively single, and it is difficult to realize the coordinated stimulation of multiple brain regions, which limits its application in the modulation of multiple nodes in the brain network. This paper first proposes a multi-target temporal interference magnetic stimulation system with array coils. The array coils are composed of seven coil units with an outer radius of 25 mm, and the spacing between coil units is 2 mm. Secondly, models of human tissue fluid and the human brain sphere are established. Finally, the relationship between the movement of the focus area and the amplitude ratio of the difference frequency excitation sources under time interference is discussed. The results show that in the case of a ratio of 1:5, the peak position of the amplitude modulation intensity of the induced electric field has moved 45 mm; that is, the movement of the focus area is related to the amplitude ratio of the difference frequency excitation sources. The conclusion is that multi-target temporal interference magnetic stimulation with array coils can simultaneously stimulate multiple network nodes in the brain region; rough positioning can be performed by controlling the conduction of different coils, fine-tuning the position by changing the current ratio of the conduction coils, and realizing accurate stimulation of multiple targets in the brain area.

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A novel non-invasive brain stimulation technique: “Temporally interfering electrical stimulation”

Cited by 18 publications

References 76 publications

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric Fields

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric Fields

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Optimal Design of Array Coils for Multi-Target Adjustable Electromagnetic Brain Stimulation System

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