A novel non-invasive score for the prediction of advanced fibrosis in patients with chronic hepatitis B

Macrophage-2-Binding Protein Glycosylation Isomer (M2BPGi) and AGAP Score as Markers of Noninvasive Test for Liver Fibrosis versus FibroScan in Chronic Hepatitis B Patients: A Retrospective Observational Study

“…The AGAP score in Table 1 shows a negative result in more no/lowgrade fibrosis (100%) than advanced fibrosis (52.8%). This is in accordance with the results of a study by Okdemir and Cakmak, which showed that subjects with a low degree of fibrosis or who did not experience liver fibrosis (F0-F2) had a negative AGAP score [9].…”

“…In this study, the median AST levels in both groups were within normal limits, but the group of subjects with advanced fibrosis had a median AST and GGT level higher than the group of subjects with no/low-grade fibrosis. This is consistent with the study of Okdemir and Cakmak, who found that the median AST and GGT levels were higher in advanced fibrosis, although they did not exceed twice the upper limit of the normal value (median AST no/low-grade fibrosis 34 (24-61.5) U/L and advanced fibrosis 53 (36-93) U/L) and the median GGT level no/low-grade fibrosis 27.5 (16-50) U/L and advanced fibrosis 73 (39-117) U/L) [9]. Based on the characteristics of the study subjects (Table 1), positive M2BPGi results with advanced fibrosis were higher than those with no/low-grade fibrosis.…”

“…The AGAP Score Calculation. The AGAP score is calculated using the AGAP score formulation: AST level U/ L × GGT level U/L × age years /platelet count 10 9 /L 2 , where the AGAP score is ≤4.038, which means negative, and >4.038, which means positive, as recommended by Okdemir and Cakmak [9]. Platelet count examination used whole blood specimens in tubes with EDTA anticoagulant and was carried out using the XN-1000 hemology analyzer.…”

“…The AGAP score is also included in the latest noninvasive tests published in early 2022. The AGAP score uses the parameters AST, gamma-glutamyl transferase (GGT), age, and platelet count in its calculations [9]. This study is aimed at determining the validity of examining M2BPGi levels and AGAP scores on the Fibroscan examination as markers of noninvasive liver fibrosis in chronic hepatitis B patients.…”

A novel model predicted liver cirrhosis constructed by ultrasound and serological in autoimmune liver hepatitis

“…[3][4][5][6] Aspartate aminotransferase-to-platelet ratio index (APRI) and FIB4 ([age × AST] ÷ [PLT × ALT]) are the most commonly used serological indexes. [7,8] Ultrasound examination indexes include elasticity, [9] liver capsule smoothness, gallbladder wall smoothness, splenomegaly and so on. [10,11] There is a lack of stability with serological indexes, and the ultrasound indexes can reflect the general changes of the liver, but they do not evaluate the function of the liver.…”