A novel organic–inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets

Zhang, Junling; Chen, Gang; Tian, Miaomiao; Li, Ruigang; Quan, Xiangyin; Jia, Qiong

doi:10.1016/j.talanta.2013.06.058

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…Two-photon excitation fluorescence detection was used demonstrating a way to achieve UV fluorescence detection for polyaromatic hydrocarbons (PAHs) with substrates that would usually block such wavelengths [43]. An organic-inorganic hybrid monolith integrating alumina nanoparticles was used for the extraction and separation of 2-amino-4-chlorophenol in a PMMA (poly(methyl methacrylate)) chip [44]. Following the sample extraction, the analyte was detected using an integrated optical fiber connected to a UV-Vis spectrometer with reported limit of detection values under 10 ppb.…”

Section: Discussionmentioning

confidence: 99%

Advances in and prospects of microchip liquid chromatography

Grinias

Kennedy

2016

TrAC Trends in Analytical Chemistry

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This review focuses on recent advances in the field of microfluidic liquid chromatography from January 2013 through April 2015. Articles are organized by the type of stationary phase support focusing on device fabrication, column preparation, and use for specific applications. Additionally, a comprehensive table comparing chromatographic figures of merit for the work described is included as Appendix A as a reference for readers.

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Section: Discussionmentioning

confidence: 99%

Advances in and prospects of microchip liquid chromatography

Grinias

Kennedy

2016

TrAC Trends in Analytical Chemistry

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“…Arguably, their success has been the result of the high porosity and surface-volume ratio, high adsorptivity, and dispersibility in organic solvents, as well as the hydroxyl functional group, which together render them suitable for incorporation into sorbents for separation processes [118,119]. For instance; Li, Zhou, Tong, and Jia [119] by means of a copolymerisation technique developed poly(NIPAAm-coMBAAm-Al 2 O 3 ) for the detection of synthetic dyes such as Tartrazine, Sunset Yellow, Allura Red, Azorubine in food.…”

Section: Alumina Nanoparticlesmentioning

confidence: 99%

“…An optimised amount of alumina particles in the copolymerisation process was able to result in the minimisation of swelling in the monolith, reduce the back pressure, and enhance the surface area. Similarly, Zhang, Chen, Tian, Li, Quan, and Jia [118] applied the same approach to develop a poly(MAA-co-EGDMA-Al 2 O 3 ) monolith in a microfluidic chip for the detection of 2-amino-4-chlorophenol in chlorzoxazone tablets. It was evident from their physicochemical characterisation via FT-IR and SEM analysis that their copolymerisation process was a success.…”

Section: Alumina Nanoparticlesmentioning

confidence: 99%

Nano-Doped Monolithic Materials for Molecular Separation

et al. 2017

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Monoliths are continuous adsorbents that can easily be synthesised to possess tuneable meso-/macropores, convective fluid transport, and a plethora of chemistries for ligand immobilisation. They are grouped into three main classes: organic, inorganic, and hybrid, based on their chemical composition. These classes may also be differentiated by their unique morphological and physicochemical properties which are significantly relevant to their specific separation applications. The potential applications of monoliths for molecular separation have created the need to enhance their characteristic properties including mechanical strength, electrical conductivity, and chemical and thermal stability. An effective approach towards monolith enhancement has been the doping and/or hybridization with miniaturized molecular species of desirable functionalities and characteristics. Nanoparticles are usually preferred as dopants due to their high solid phase dispersion features which are associated with improved intermolecular adsorptive interactions. Examples of such nanomaterials include, but are not limited to, carbon-based, silica-based, gold-based, and alumina nanoparticles. The incorporation of these nanoparticles into monoliths via in situ polymerisation and/or post-modification enhances surface adsorption for activation and ligand immobilisation. Herein, insights into the performance enhancement of monoliths as chromatographic supports by nanoparticles doping are presented. In addition, the potential and characteristics of less common nanoparticle materials such as hydroxyapatite, ceria, hafnia, and germania are discussed. The advantages and challenges of nanoparticle doping of monoliths are also discussed.

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“…Nanoparticle functionalization can be used to change the characteristics of a porous polymer monolith. Zhang et al 59 fabricated an alumina nanoparticle modified methacrylic acid-co-poly(ethylene glycol) diacrylate (PEGDA) monolith in a PMMA microfluidic device. Using optimized conditions of solution pH, flow rate, and different times, the device was used for SPE of 2-amino-4-chlorophenol content in chlorzoxazone tablets.…”

Section: B Ionic Interactionmentioning

confidence: 99%

Advances in monoliths and related porous materials for microfluidics

2016

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In recent years, the use of monolithic porous polymers has seen significant growth. These materials present a highly useful support for various analytical and biochemical applications. Since their introduction, various approaches have been introduced to produce monoliths in a broad range of materials. Simple preparation has enabled their easy implementation in microchannels, extending the range of applications where microfluidics can be successfully utilized. This review summarizes progress regarding monoliths and related porous materials in the field of microfluidics between 2010 and 2015. Recent developments in monolith preparation, solid-phase extraction, separations, and catalysis are critically discussed. Finally, a brief overview of the use of these porous materials for analysis of subcellular and larger structures is given.

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A novel organic–inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets

Cited by 16 publications

References 25 publications

Advances in and prospects of microchip liquid chromatography

Advances in and prospects of microchip liquid chromatography

Nano-Doped Monolithic Materials for Molecular Separation

Advances in monoliths and related porous materials for microfluidics

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