Molecular Medicine 2019
DOI: 10.5772/intechopen.81567
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A Novel P53/POMC/Gas/SASH1 Autoregulatory Feedback Loop and Pathologic Hyperpigmentation

Abstract: P53-regulated proteins in transcriptional level are associated with many signal transduction pathways and p53 plays a pivotal role in a number of positive and negative autoregulatory feedback loops. Although POMC/α-MSH productions induced by ultraviolet (UV) are directly mediated by p53, p53 is related to UV-independent pathological pigmentation. In the process of identifying the causative gene of dyschromatosis universalis hereditaria (DUH), three mutations encoding amino acid substitutions were found in the … Show more

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“…Beyond its roles in tumorigenesis, SASH1 has also been demonstrated to be involved in the regulation of melanogenesis by a novel p53/POMC/α‐MSH/Gαs/SASH1 cascade. Highlighting this, mutations in SASH1 resulting in hyperpigmentation 19 21 .…”
Section: Introductionmentioning
confidence: 99%
“…Beyond its roles in tumorigenesis, SASH1 has also been demonstrated to be involved in the regulation of melanogenesis by a novel p53/POMC/α‐MSH/Gαs/SASH1 cascade. Highlighting this, mutations in SASH1 resulting in hyperpigmentation 19 21 .…”
Section: Introductionmentioning
confidence: 99%