A novel paclitaxel‐eluting porous carbon–carbon nanoparticle coated, nonpolymeric cobalt–chromium stent: Evaluation in a porcine model

Bhargava, Balram; Reddy, N. Krishna; Karthikeyan, Ganesan; Raju, Raghava; Mishra, Sundeep; Singh, Sandeep; Waksman, Ron; Virmani, Renu; Somaraju, B.

doi:10.1002/ccd.20698

Cited by 65 publications

(34 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It appears that the coating is initially a polymer-based slurry with carbon particles dispersed; subsequent pyrolysis converts the mixture to this carbon-carbon matrix, with porosity controlled by the carbon particle size and the extent of pyrolysis. A porcine study using this drug-loaded coating, on a cobaltchromium stent, showed the concept to be both safe and effective, though the study did lack a suitable control arm [70]. Going forward, it will be interesting to see the significance of any residual polymer that may be present in the structure, i.e.…”

Section: Porous Carbon-carbon Coatingmentioning

confidence: 97%

The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: A review

2009

View full text Add to dashboard Cite

Section: Porous Carbon-carbon Coatingmentioning

confidence: 97%

The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: A review

2009

View full text Add to dashboard Cite

“…Because the polymer is retained on the stent platform following the drug release, it has been hypothesized that the chronic presence of polymer can trigger an inflammatory response, contributing to restenosis and thrombosis. 20 Thus, the definition of polymer biocompatibility has to be extended to include the extent of inflammatory effect that the polymer may exert on adjacent cells. The mechanism by which polymeric coatings may induce inflammatory response is not well defined.…”

Section: Biocompatibilitymentioning

confidence: 99%

Impact of polymer hydrophilicity on biocompatibility: Implication for DES polymer design

Hezi-Yamit

Sullivan

Wong

et al. 2008

J Biomedical Materials Res

144

View full text Add to dashboard Cite

Polymer coatings are essential for local delivery of drug from the stent platform. In designing a DES, it is critical to balance the hydrophilic and hydrophobic components of the polymer system to obtain optimal biocompatibility, while maintaining controlled drug elution. This study investigates the impact of polymer composition of the BioLinx polymer blend on in vitro biocompatibility, as measured by monocytic adhesion. Comparable evaluation was performed with polymers similar to those utilized in various DES that are currently being marketed. Relative hydrophilicities of polymer surfaces were determined through contact angle measurements and surface analyses. Polymer biocompatibility was evaluated in a novel in vitro assay system in which activated monocyte cells were exposed to polymer coated on 96-well plates. Enhanced monocyte adhesion was observed with polymers of a more hydrophobic nature, whereas those which were more hydrophilic did not induce activated monocyte adhesion. Our data supports the hypothesis that polymer composition is a feature that dictates in vitro biocompatibility as measured by monocyte driven inflammation. Monocyte adhesion has been shown to induce local inflammation as well as promote vascular cell proliferation factors contributing to in stent restenosis (Rogers et al., Arterioscler Thromb Vasc Biol 1996;16:1312-1318). Observed results suggest hydrophobic but not hydrophilic polymer surfaces support adhesion of activated monocytes to the polymer scaffold. The proprietary DES polymer blend BioLinx has a hydrophilic surface architecture and does not induce an inflammatory response as measured by these in vitro assays.

show abstract

“…A porous surface formed by carbon nanoparticles embedded in polymer has displayed promise as a means for localized drug delivery [116]. Similarly, cobalt-chromium alloy stents covered with a porous carbon-carbon coating also showed potential in the arena of drug elution and enhanced cell attachment [116].…”

Section: Porous Surfaces To Facilitate Drug Deliverymentioning

confidence: 99%

“…Similarly, cobalt-chromium alloy stents covered with a porous carbon-carbon coating also showed potential in the arena of drug elution and enhanced cell attachment [116].…”

Section: Porous Surfaces To Facilitate Drug Deliverymentioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

View full text Add to dashboard Cite

Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

show abstract

A novel paclitaxel‐eluting porous carbon–carbon nanoparticle coated, nonpolymeric cobalt–chromium stent: Evaluation in a porcine model

Abstract: This preclinical evaluation demonstrates the safety and efficacy of a novel cobalt chromium stent with a carbon-carbon coating and low and medium doses of paclitaxel.

Cited by 65 publications

References 13 publications

The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: A review

The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: A review

Impact of polymer hydrophilicity on biocompatibility: Implication for DES polymer design

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Contact Info

Product

Resources

About