2004
DOI: 10.1159/000077543
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A Novel Permutation Testing Method Implicates Sixteen Nicotinic Acetylcholine Receptor Genes as Risk Factors for Smoking in Schizophrenia Families

Abstract: Smoking is a common correlate of schizophrenia, which leads to medical morbidity. Although twin and adoption studies have consistently implicated genes in the etiology of both smoking and schizophrenia, finding genes has been difficult. Several authors have suggested that clinical or neurobiological features associated with schizophrenia, such as smoking, might improve the ability to detect schizophrenia susceptibility genes by identifying genes related to the etiology of that feature. The objective of this st… Show more

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Cited by 51 publications
(32 citation statements)
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“…Although CHRNA2 had been previously implicated in nicotine dependence in schizophrenic families (Faraone et al, 2004), evidence for a contribution of CHRNA2 to antisocial drug dependence is novel. However, evidence for a role of brain-expressed neuronal nicotinic receptors on substance dependence is quickly accumulating.…”
Section: Discussionmentioning
confidence: 99%
“…Although CHRNA2 had been previously implicated in nicotine dependence in schizophrenic families (Faraone et al, 2004), evidence for a contribution of CHRNA2 to antisocial drug dependence is novel. However, evidence for a role of brain-expressed neuronal nicotinic receptors on substance dependence is quickly accumulating.…”
Section: Discussionmentioning
confidence: 99%
“…In rodents, a4b2 subunit of nAChRs, but not a7, appears to regulate acoustic PPI (Schreiber et al, 2002). However, there is strong evidence suggesting that a7 nAChR (for a recent review see Martin and Freedman, 2007) and to a lesser extent a4b2 nAChR (Breese et al, 2000;Durany et al, 2000;Marutle et al, 2001;Faraone et al, 2004;De Luca et al, 2006) are involved in the pathology of schizophrenia. Subtype-specific nAChRs compounds are now becoming available for human studies.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, in the case of schizophrenia, all programs identify the same candidate gene for all regions, and it is not the one expected. The candidate gene identified, CHRNA2, has been reported as not increasing the susceptibility to schizophrenia, according to one study by Blaveri et al (2001), but may play a particular role in the nicotinic system in smoking for schizophrenic families, according to another study by Faraone et al (2004). By limiting the mean total ranking of the three software tools to the 10 Mb region, three of four of the expected candidate genes are ranked as the most probable.…”
Section: Discussionmentioning
confidence: 99%