A novel pillar[5]arene-based supramolecular fluorescent biomaterial for targeted accumulation and imaging of kidney

Yang, Xia; Xiao, Han; He, Jiao; Li, Yang; Tao, Zhu; Xiao, Xin; Li, Qiu; Yang, Haiping

doi:10.1016/j.snb.2023.134065

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Untreated cell culture was performed as outlined in our previous study . The human proximal tubular cell line (HK2 cells) was cultured in DMEM-F12 medium with 10% fetal bovine serum (FBS) and 100 U/mL penicillin/streptomycin.…”

Section: Methodsmentioning

confidence: 99%

“…Untreated cell culture was performed as outlined in our previous study. 36 The human proximal tubular cell line (HK2 cells) was cultured in DMEM-F12 medium with 10% fetal bovine serum (FBS) and 100 U/mL penicillin/streptomycin. The human mesangial cells (HMCs) and human podocytes (HPCs) were grown in RPMI-1640 medium containing 10% FBS and 100 U/mL penicillin/streptomycin.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…These sensors offer notable benefits such as high sensitivity, excellent selectivity, rapid response, and ease of operation. , The sensors can be used to detect a variety of biomarkers, including ions, − small molecules, − and proteins, − enabling monitoring and diagnosis of biological processes and disease states. In recent years, there has been a significant research effort directed at the application of supramolecular chemistry in the production of fluorescent sensors for detecting markers of renal insufficiency. − These supramolecular fluorescent sensors have the ability to qualitatively or quantitatively assess the status of renal insufficiency by selectively recognizing and responding to specific markers associated with renal dysfunction. This recognition and response result in visible changes to the fluorescent signals.…”

mentioning

confidence: 99%

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Cucurbit[8]uril-Based Supramolecular Probe for the Detection of 3-Nitrotyrosine in Human Serum and Plasma

Xiao,

Ren,

et al. 2024

ACS Sens.

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The biomarker 3-nitrotyrosine (3-NT) is widely recognized as an indicator of renal oxidative stress injury, making its detection crucial for the early identification of renal insufficiency. This study presents the design and synthesis of a tetraphenylstyrene imidazole derivative (TIPE-MI), which is utilized to create a supramolecular probe in conjunction with cucurbit[8]uril (Q[8]) through host−guest interactions. The resulting supramolecular selfassembly exhibits excellent optical properties and has been employed for the specific detection of 3-NT through fluorescence quenching. The introduction of 3-NT resulted in a decreased fluorescence intensity of the yellow fluorescent probe, which gradually transitioned from bright yellow to light yellow and then became colorless as the 3-NT concentration was increased. A portable detection platform was devised to augment the efficiency of detection. In order to facilitate biological applications, we have substantiated the probe's exceptional precision in detecting 3-NT in biological samples, encompassing human serum and plasma. The probe also exhibited negligible cytotoxicity. The accumulation of the probe in renal cells elicited a fluorescence signal, thereby indicating the prospective viability of this system for visual detection with renal cytocompatibility.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cucurbit[8]uril-Based Supramolecular Probe for the Detection of 3-Nitrotyrosine in Human Serum and Plasma

Xiao,

Ren,

et al. 2024

ACS Sens.

Self Cite

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“…In conclusion, PSPs not only inherit numerous advantages of conventional covalent polymers but also offer distinct characteristics[43].Pillar[n]arene has been widely used in a variety of scopes ascribed to the structural symmetry, easy synthesis, and functionalization with different substituents on every benzene ring. The exceptional attributes of PSPs have led to their extensive utilization in areas such as sensor arrays[44][45][46][47], substance separation materials[48], catalysis, lightharvesting systems, controlled drug release, as well as membrane delivery and various other domains[49][50][51][52][53][54][55][56]. Some reviews about the designs and applications of PSPs have been reported earlier, especially related to pillar[5]arene (Table1).…”

mentioning

confidence: 99%

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Li,

Jin,

Zhu

et al. 2023

Polymers

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Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating a “bottom-up” approach to govern the sizes and structures of supramolecular materials. Using dynamic non-covalent interactions, supramolecular polymers can create materials with reversible and degradable characteristics and the abilities to self-heal and respond to external stimuli. Pillar[n]arene represents a novel class of macrocyclic hosts, emerging after cyclodextrins, crown ethers, calixarenes, and cucurbiturils. Its significance lies in its distinctive structure, comparing an electron-rich cavity and two finely adjustable rims, which has sparked considerable interest. Furthermore, the straightforward synthesis, uncomplicated functionalization, and remarkable properties of pillar[n]arene based on supramolecular interactions make it an excellent candidate for material construction, particularly in generating interpenetrating supramolecular polymers. Polymers resulting from supramolecular interactions involving pillar[n]arene find potential in various applications, including fluorescence sensors, substance adsorption and separation, catalysis, light-harvesting systems, artificial nanochannels, and drug delivery. In this context, we provide an overview of these recent frontier research fields in the use of pillar[n]arene-based supramolecular polymers, which serves as a source of inspiration for the creation of innovative functional polymer materials derived from pillar[n]arene derivatives.

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Phenyl‐Extended Resorcin[4]arenes: Synthesis and Highly Efficient Iodine Adsorption

Li,

Wu,

Zhu

et al. 2024

Angewandte Chemie

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The continuous exploration of new analogs of calixarenes and pillararenes unlocks infinite opportunities in supramolecular chemistry and materials. In this work, we introduce a new class of macrocycle, phenyl‐extended resorcin[4]arenes (ExR4), a unique and innovative design that incorporates unsubstituted phenylene moieties into the resorcin[4]arene scaffold. Single‐crystal analysis reveals a chair‐like conformation for per‐methylated ExR4 (Me‐ExR4) and a twisted "figure‐of‐eight" shaped conformation for per‐hydroxylated ExR4 (OH‐ExR4). Notably, OH‐ExR4 demonstrates exceptional adsorption capability toward I3− ions in an aqueous solution, with a rapid kinetic rate of 1.18×10‐2 g·mg‐1·min‐1. Furthermore, OH‐ExR4 shows excellent recyclability and potential as a stationary phase in column setups. The discovery of ExR4 opens up new avenues for constructing new macrocycles and inspires further research in functional adsorption materials for water pollutant removal.

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A novel pillar[5]arene-based supramolecular fluorescent biomaterial for targeted accumulation and imaging of kidney

Cited by 5 publications

References 48 publications

Cucurbit[8]uril-Based Supramolecular Probe for the Detection of 3-Nitrotyrosine in Human Serum and Plasma

Cucurbit[8]uril-Based Supramolecular Probe for the Detection of 3-Nitrotyrosine in Human Serum and Plasma

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Phenyl‐Extended Resorcin[4]arenes: Synthesis and Highly Efficient Iodine Adsorption

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