A novel point-of-care technique to improve graft uptake in a melanocyte-keratinocyte transplantation procedure for vitiligo of contoured areas such as the external ear

Bansal, Akshi; Shilpa, Kanathur; Prasad, Harikrishnan

doi:10.1016/j.jaad.2020.05.117

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…A dental putty material was molded by application to the recipient's ear before dermabrasion. The same was used to sandwich the transplanted cells and dressing to retain the suspension at the recipient site, resulting in excellent repigmentation 51 …”

Section: Transplanting At Special Sitesmentioning

confidence: 99%

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Transplantation procedures in vitiligo: What's new

Thakur

Parsad

2022

Dermatological Reviews

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Background: Transplantation plays a pivotal role in vitiligo surgery and has advanced at a galloping pace.Objectives: To enlist the latest developments in vitiligo transplantation surgery.Findings: Advancements in clinico-epidemiological and molecular profiling (CD8, CD45RO, CXCL-9) have enabled us to predict response to treatment better than ever before. The pace of transplantation has been augmented and the hassle of properly orienting the graft has been bypassed. The pallet has been expanded with a better donor to recipient ratio and ease of technique with regard to hair follicle transplants and suspensions. Suspending media have had a makeover, becoming less runner with a greater rate of pigmentation. Science has made the procedure more pocket and equipment friendly, be it in the realm of incubation or inhibition of trypsin. Electrofulguration, cryogens, salicylic and lactic acid, dental burrs, and lasers have made recipient site preparation easier. Adversity has been metamorphosed into an advantage by harvesting and transplanting the cobblestone that appears post-mini-punch grafting. Surgical techniques have been crafted to conform to special sites like the fingers, palmoplantar sites, ears, genitals, and nipple-areola. Conclusion:There have been many significant advancements in the field of vitiligo transplantation surgery in recent years especially in terms of ease of technique, minimal invasiveness, the pain associated with the procedure, and success rates.

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Section: Transplanting At Special Sitesmentioning

confidence: 99%

“…The same was used to sandwich the transplanted cells and dressing to retain the suspension at the recipient site, resulting in excellent repigmentation. 51…”

Section: Contoured Areas Of the Earmentioning

confidence: 99%

Transplantation procedures in vitiligo: What's new

Thakur

Parsad

2022

Dermatological Reviews

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“…[46] In order to retain the transplanted material on uneven contours, a putty material can be used as a scaffold. [47] Advantages of NCES include coverage of large areas in single sitting, good cosmetic outcomes, and excellent color match [Figure 4].…”

Section: Cultured Melanocyte Transplantationmentioning

confidence: 99%

Surgical modalities of treatment in vitiligo

Thakur

Vinay

et al. 2021

CSDM

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Vitiligo is an acquired disorder of depigmentation that is associated with immense stigma and psychological burden. Although there is a myriad of options available for therapy, the repigmentation is best achieved with surgical modalities for stable disease. Once the immune attack on melanocyte is halted, surgery can be undertaken. The principles of surgery may be to introduce artificial pigment, stimulate melanocyte proliferation and migration, removal of depigmented areas or repopulation of depleted melanocytes. Broadly these can be divided into grafting, non-grafting techniques, camouflage and excision. The grafting techniques are further divided into cellular and tissue grafts. The advantage of the former being a greater donor to recipient ratio, however with added cost and equipment requirement. Grafting techniques have undergone various innovations, be it in harvesting, recipient site preparation or dressing, each with their own advantages and disadvantages. New innovations continue to crop up, including the use of stem cells and regulatory T-cell modulation. A well performed surgery is incomplete if it was not done without proper patient selection, counseling and preparation. This review article briefly outlines the various techniques; pre, intra and post-operative intricacies and the innovations in each.

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