A Novel Polyphenolic Hydrogels Therapeutic Strategy for Diabetic Wounds Repair

Abstract

As we all know, diabetes patients greatly decrease their quality of life and increase their economic burden. Tissue regeneration in diabetic wounds is a worldwide clinical challenge due to immune, genetic, and environmental factors. Severe infectious wounds in diabetic patients can potentially result in sepsis even amputation. Hence, it is necessary to use a rapid treatment strategy for effective anti-infection with hydrogel materials. Polyphenol polymers may quickly suppress reactive oxygen species of chronic inflammation for diabetic wounds. However, the instability of polyphenols reduces the rate of wound healing, using a hydrogel carrier as a carrier can improve the stability of polyphenolic compounds and control their release to accelerate wound healing. This review elaborates on diabetic wound pathogenesis, the therapeutic effect of polyphenolic hydrogel, including its preparation and stability, and the construction of the diabetes model, which provides a reference for the clinical treatment of diabetes.