A novel population pharmacokinetic model for recombinant factor IX-Fc fusion concentrate including young children with haemophilia B
Sjoerd Koopman,
Tine Goedhart,
Laura Bukkems
et al.
Abstract:Background Recombinant factor IX Fc fusion protein (rFIX-Fc) is an
extended half-life (EHL) factor concentrate administered to haemophilia
B patients. So far, a population pharmacokinetic (PK) model has only
been published for patients ≥12 years of age. Aim Assess the predictive
performance of the published rFIX-Fc population PK model for patients of
all ages and develop a model that describes rFIX-Fc PK using real world
data. Methods We collected prospective and retrospective data from
patients with haemophil… Show more
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