The quality of gear manufacturing significantly influences the way load is distributed in meshing gears. Despite this being well-known from practical experience, gear quality effects were never systematically characterized for polymer gears in a manner able to account for them in a standard calculation process. The present study employs a novel combination of numerical and experimental methods, leading to a successful determination of these effects. The findings of the study enhance existing gear design models and contribute to a more optimized polymer gear design. The study first explores the effect of injection-molding parameters on the gear quality and secondly the effect of resulting gear quality on the stress conditions in a polymer gear pair. For the gear sample production, different combinations of process parameters were investigated, and a classic injection-molding and the Variotherm process were utilized. Gear quality and crystallinity measurements were conducted for all produced gears, providing insights into the correlation between them. Based on the evaluated gear quality of produced samples, the effect of gear quality was further studied by numerical means within a meaningful range of quality grades and transmitted loads. Special attention was dedicated to lead and pitch deviations, which were found to exert a noteworthy influence on the stress state (both root and flank) of the gear. The effect of lead deviation was most pronounced when improving the gear quality from grade Q12 to grade Q10 (30% to 80% stress reduction, depending on the load). However, enhancing the quality grade from Q10 to Q8 yielded less improvement (5% to 20% stress reduction, depending on the load). A similar pattern was evident also for pitch deviations.