A novel predictive model for new-onset atrial fibrillation in patients after isolated cardiac valve surgery

Heng, Y.; Chen, Yuan; Yang, Juesheng; Xiang, Hao; Lan, Wanqi; Tang, Yanhua

doi:10.3389/fcvm.2022.949259

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…In agreement with previous data, patients who developed POAF were older and had longer left atrial diameter compared with those who did not. These characteristics are perceived as the basis of atrial fibrosis, possibly reflecting a preexisting susceptible atrial substrate that is indispensable for the generation of POAF (Corradi et al, 2020; Axtell et al, 2020; Akintoye et al, 2018; Yang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Levels of Nicotinamide-Adenine Dinucleotide Phosphate Oxidase 2 and the Development of Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting: A Prospective Pilot Study

Yan

Zhang

et al. 2023

Biological Research For Nursing

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Introduction To investigate the levels of nicotinamide-adenine dinucleotide phosphate oxidase 2 (NOX2) in serum and pericardial drainage samples in the early stage after coronary artery bypass grafting (CABG) and determine whether NOX2 is predictive of postoperative atrial fibrillation (POAF). Materials and Methods This prospective pilot study involved 152 adults without history of atrial fibrillation who underwent first-time elective isolated CABG. Serum and pericardial fluid samples were simultaneously obtained from patients at baseline and 4, 12, and 24 h post operation. NOX2 levels were determined using enzyme-linked immunosorbent assays. The heart rhythm of patients was continuously monitored through a Holter monitor until discharge. Logistic regression and receiver-operating characteristic (ROC) curve analyses were performed, as appropriate. Results Fifty-one patients (33.6%) experienced in-hospital POAF. NOX2 concentration in serum and pericardial drainage samples was increased after surgery, reached its peak at 12 h, and gradually declined thereafter toward the baseline levels by 24 h. At 12 h, patients with POAF had higher levels of serum NOX2 than those without (3.96 ± 0.35 vs. 3.70 ± 0.75 μg/mL, respectively, p = 0.004). There were no discernible differences in pericardial NOX2 between the 2 groups. Multivariate analysis revealed that serum NOX2 at 12 h post operation was the strongest independent predictor of POAF (odds ratio: 2.179, 95% confidence interval: 1.084–4.377). The area under the ROC curve of the POAF predictive model was 0.732 (95% confidence interval: 0.654–0.801). Conclusion Serum NOX2 may be useful in the identification of POAF. Larger studies are warranted to substantiate these findings.

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