A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Feng, J.; Wang, Liang; Jiang, Yongxin; Yang, Xun

doi:10.24875/ric.19003184

“…26 In addition, similar conclusions have been drawn in digestive system tumors such as gastric cancer, pancreatic cancer, esophageal cancer, and so on: the prognosis of patients tends to become worse with the increase of FPR. 14,27,28 Some researchers believe that the combined score of FPR and PNI can predict the prognosis of elderly patients with gastric cancer, but FPR is not an independent prognostic factor for elderly patients with gastric cancer, which is different from our results. 15 Additionally, in the subgroup analysis, we employed univariate and multivariate Cox analyses to mitigate the influence of confounding factors, delving deeper into the significance of FPR in predicting prognosis across different subsets of gastric cancer patients.…”

Section: Discussioncontrasting

confidence: 99%

Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer

Li,

Sun,

Wang

et al. 2024

JIR

1

0

View full text Add to dashboard Cite

Background:The ratio of fibrinogen to prealbumin (FPR) is associated with the prognosis of many cancers. However, the prognostic significance of FPR in resectable gastric cancer has not been clarified. Methods: A total of 760 patients with resectable gastric cancer participated in this study. The receiver operating characteristic curve (ROC) was used to calculate the optimal cutoff value of each immunonutrition marker. Univariate and multivariate Cox regression analyses were used to confirm the prognostic value of FPR in patients with gastric cancer and to select appropriate variables for the construction of nomogram. Results: Utilizing ROC analysis, we calculated the optimal cutoff value for FPR and stratified 760 patients into high and low FPR groups. Subsequent examination revealed notable distinctions in baseline characteristics between these groups. For instance, Patients with higher FPR tend to be older and have more lymph node metastasis. Statistical analysis through the chi-square test confirmed the significance of these differences (P < 0.05). In addition, the results of the multivariate Cox proportional hazards regression analysis indicate that the factors related to OS were age (P = 0.001), T stage (P < 0.001), N stage (P < 0.001), radical resection (P < 0.001), and FPR (P < 0.024). The nomogram is composed of the above five variables. ROC analysis showed that the area under the curve (AUC) of the nomogram was 0.859 (95% CI: 0.831-0.887), and the sensitivity and specificity were 77.4% and 82.1%, respectively. Conclusion: FPR is a potential marker in patients with resectable gastric cancer. The nomogram based on FPR shows good predictive ability, which is helpful for clinicians to judge the prognosis of patients and choose targeted treatment strategies.

show abstract

“…that FPR can evaluate the prognosis of malignant tumors such as colorectal cancer, hepatocellular carcinoma, esophageal cancer and gastric cancer (13)(14)(15)35). A recent meta-analysis pointed out that high value of FPR is associated with poorer survival and increased risk of recurrence in cancer patients (36).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, more biomarkers are needed to help guide therapy and improve the accuracy of prognostic determinations for individual patients. As a novel serological prognostic marker, multiple studies have demonstrated that FPR can evaluate the prognosis of malignant tumors such as colorectal cancer, hepatocellular carcinoma, esophageal cancer and gastric cancer ( 13 – 15 , 35 ). A recent meta-analysis pointed out that high value of FPR is associated with poorer survival and increased risk of recurrence in cancer patients ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fibrinogen-to-prealbumin ratio: A new prognostic marker of resectable pancreatic cancer

Li

¹

,

Fan

²

,

Guo

³

et al. 2023

View full text Add to dashboard Cite

BackgroundThe fibrinogen-to-prealbumin ratio (FPR), a novel immune-nutritional biomarker, has been reported to be associated with prognosis in several types of cancer, but the role of FPR in the prognosis of resectable pancreatic cancer has not been elucidated.MethodsA total of 263 patients with resectable pancreatic cancer were enrolled in this study and were randomly divided into a training cohort (n = 146) and a validation cohort (n = 117). Receiver operating characteristic curve (ROC) was used to calculate the cut-off values of immune-nutritional markers. The least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression were performed in the training cohort to identify the independent risk factors, based on which the nomogram was established. The performance of the nomogram was evaluated and validation by the training and validation cohort, respectively.ResultsThe optimal cutoff value for FPR was 0.29. Multivariate analysis revealed that FPR, controlling nutritional status (CONUT), carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and tumor node metastasis (TNM) stage were independent predictors of overall survival (OS). The nomogram was established by involving the five factors above. The C-index of the training cohort and validation cohort were 0.703 (95% CI: 0.0.646-0.761) and 0.728 (95% CI: 0.671-0.784). Decision curve analysis and time-dependent AUC showed that the nomogram had better predictive and discriminative ability than the conventional TNM stage.ConclusionFPR is a feasible biomarker for predicting prognosis in patients with resectable pancreatic cancer. The nomogram based on FPR is a useful tool for clinicians in making individualized treatment strategies and survival predictions.

show abstract

Prognostic Significance of Preoperative Fibrinogen‐to‐Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Xie

¹

,

Huang

²

,

Yuan

³

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Background. The objective of this study was to explore the role of preoperative fibrinogen-to-prealbumin ratio (FPR) in evaluating the prognosis of patients with stage I–III colorectal cancer (CRC). Methods. This retrospective study enrolled 584 stage I–III CRC patients undergoing surgical resection. Logistic regression analysis was used to explore the correlation between FPR and postoperative complications. The Kaplan-Meier curve and Cox proportional hazards model were used to identify the prognostic factors. The nomograms were constructed based on the prognostic factors. The concordance index and calibration curve were used to determine the accuracy of the nomograms. Time-dependent receiver operating characteristic was used to compare the predictive prognostic efficacy of nomograms and TNM stage. Results. FPR was determined to be an independent factor affecting postoperative complications. Patients with a low-FPR had a significantly better prognosis than those with a high-FPR (disease-free survival, p = 0.028 ; overall survival, p = 0.027 ), especially patients with stage I CRC (disease-free survival, p = 0.015 ; overall survival, p = 0.017 ). The Cox proportional hazards model identified FPR as an independent poor prognostic factor of disease-free survival (hazard ratio HR = 1.459 , 95% confidence interval CI = 1.074 –1.954, p = 0.011 ) and overall survival ( HR = 1.405 , 95% CI = 1.034 –1.909, p = 0.030 ). The prognostic nomograms had good accuracy and were superior to the traditional TNM stage. Conclusions. FPR is a potential indicator for predicting short- and long-term prognosis of stage I–III CRC patients undergoing surgical resection.

show abstract

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Cited by 4 publications

References 36 publications

Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer

Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer

Fibrinogen-to-prealbumin ratio: A new prognostic marker of resectable pancreatic cancer

Prognostic Significance of Preoperative Fibrinogen‐to‐Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Contact Info

Product

Resources

About