2022
DOI: 10.1097/md.0000000000031924
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A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review

Abstract: Lung adenocarcinoma (LUAD) is a highly heterogeneous disease with complex pathogenesis, high mortality, and poor prognosis. Cuproptosis is a new type of programmed cell death triggered by copper accumulation that may play an important role in cancer. LncRNAs are becoming valuable prognostic factors in cancer patients. The effect of cuproptosis-related lncRNAs (CRlncRNAs) on LUAD has not been clarified. Based on the Cancer Genome Atlas database, CRlncRNAs were screened by co-expression analysis of cuproptosis-r… Show more

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Cited by 4 publications
(5 citation statements)
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“…However, Wei Ye et al and Ran Chen et al ‘s study did not provide the coefficient details of their signatures, which were excluded from our choices. Finally, nine studies [ 37 40 , 42 , 43 , 45 47 ] were listed as candidates for comparison with our signature ( Table 3 ). To compare previous signatures with ours, we performed Cox regression analysis for overall, disease-specific, and progression-free survival using four formats of official TCGA data ( Figure 9 ), respectively.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…However, Wei Ye et al and Ran Chen et al ‘s study did not provide the coefficient details of their signatures, which were excluded from our choices. Finally, nine studies [ 37 40 , 42 , 43 , 45 47 ] were listed as candidates for comparison with our signature ( Table 3 ). To compare previous signatures with ours, we performed Cox regression analysis for overall, disease-specific, and progression-free survival using four formats of official TCGA data ( Figure 9 ), respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Considerable effort has been invested in validating the accuracy of our model, including a comparative analysis with previous studies. To accomplish this, we gathered all published studies [ 37 40 , 42 , 43 , 45 47 ] that were similar to our research and evaluated their performance, along with our model, on the official TCGA data ( Figure 9 ). By constructing Cox models and analyzing three different outcome endpoint data sets, namely OS, DSS, and PFS, we determined that our model generally outperformed previously published models.…”
Section: Discussionmentioning
confidence: 99%
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“…LncRNAs have been implicated in cancer in some cases. For example, the lncRNA AC090948.1 was found to be related to lipid metabolism, cuproptosis, and immunity in cancers [25][26][27]. Hu et al noticed that AC020765.2 is related to autophagy in lung cancer [28].…”
Section: Discussionmentioning
confidence: 99%
“…LUAD, recognized for its complexity, is significantly influenced by a myriad of oncogenes, cytokines and chemokines 6–8 . The complexity of LUAD is amplified by the tumour microenvironment's (TME) heterogeneity, affecting treatment, progression and response to therapies 9,10 . Understanding the TME's complex interactions is vital for creating targeted and effective treatment strategies for LUAD's multifaceted nature.…”
Section: Introductionmentioning
confidence: 99%