1987
DOI: 10.1126/science.2825356
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A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene

Abstract: Growth factors and their receptors are involved in the regulation of cell proliferation and also play a key role in oncogenesis. In this study, a novel putative kinase receptor gene, termed eph, has been identified and characterized by molecular cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and includes a cysteine-rich region in the extracellular domain. However, other features of the sequence distinguish the eph gene product from known receptors with tyrosine k… Show more

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Cited by 414 publications
(289 citation statements)
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“…16]. Indeed, the founding Eph member, EphA1, was isolated from a hepatoma cell line [17] and is overexpressed in breast, liver, lung, and colon carcinomas. Many Ephs seem to be predominantly expressed in metastatic cell lines as compared to the primary tumor, and their expression levels often correlate with the grade of the tumor malignancy and invasiveness.…”
Section: New Insights Into Functions Outside Of the Nervous Systemmentioning
confidence: 99%
“…16]. Indeed, the founding Eph member, EphA1, was isolated from a hepatoma cell line [17] and is overexpressed in breast, liver, lung, and colon carcinomas. Many Ephs seem to be predominantly expressed in metastatic cell lines as compared to the primary tumor, and their expression levels often correlate with the grade of the tumor malignancy and invasiveness.…”
Section: New Insights Into Functions Outside Of the Nervous Systemmentioning
confidence: 99%
“…Although many of the Eph-related receptors are expressed in the nervous system, their expression patterns are quite distinct as well as overlapping, suggesting that the di erent neuronally expressed Eph family members may have complementary and overlapping roles in the development of various neuronal cell populations. Earlier studies suggest that some of the Eph-like receptors may be involved in oncogenic transformation (Hirai et al, 1987;Maru et al, 1990;Kiyokawa et al, 1994). However, our results indicate that overexpression of Eek and its elevated level of tyrosine phosphorylation do not cause transformation of NIH3T3 cells.…”
Section: Discussionmentioning
confidence: 99%
“…The Figure 2 Cladogram for the Eph subfamily of receptor tyrosine kinases. The whole amino acid sequence of Eek was compared with those of Ehk-2 (Maisonpierre et al, 1993), Hek/Mek4/Cek4 (Sajjadi et al, 1991), Bsk/Ehk1/Rek7/Cek7 (Zhou et al, 1994), Ehk-3/MDK1 (Valenzuela et al, 1995;Ciossek et al, 1995), Sek/ Cek8 (Gilardi-Hebenstreit et al, 1992), Elk/Cek6 (Letwin et al, 1988;Lhotak et al, 1991), Cek5/Erk/Nuk (Henkemeyer et al, 1994), Hek2/Sek4/Cek10 (Bohme et al, 1993), Myk1 (Andres et al, 1994), Eck/Sek2 (Lindberg and Hunter, 1990), and Eph (Hirai et al, 1987) using the PILEUP program (GCG). The 42 amino acid insert, present between kinase motifs IV and V in the Ehk-2 kinase domain was deleted for comparison as previously described (Maisonpierre et al, 1993).…”
Section: Nih3t3 Cells Have Endogenous Ligands For the Eek Receptormentioning
confidence: 99%
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“…The previous ®nding that the EphB2 receptor and its TM ligands are phosphorylated on tyrosine residues in mouse embryos suggests a role for these molecules in development (BruÈ ckner et al, 1997). Moreover, transcripts of both EphA1 and EphB2 are known to be overexpressed in some types of human carcinomas (Easty et al, 1995;Hirai et al, 1987;Maru et al, 1988;Kiyokawa et al, 1994). The observation that various neuroectodermal tumor cell lines express EphB2 transcripts of aberrant sizes (Ikegaki et al, 1995), also demonstrates that Eph receptors may play important roles in carcinogenesis.…”
Section: Introductionmentioning
confidence: 98%