A novel radiofrequency device for the treatment of rhytides and lax skin: A pilot study

Background Carboxytherapy is capable of inducing tissue repair which results in an increase in elastic and collagen fibers. Objectives To evaluate the effects of carboxytherapy upon human skin collagen and elastic fiber synthesis. Methods Case study of nine volunteers who received a single application of carboxytherapy in the left infraumbilical region, with infusion rate of 100 mL/min and 0.6 mL/kg weight over an area of 25 cm2. After 60 days on average, the skin was collected for histological analysis and stained with picrosirius red for collagen and Verhoeff for elastic fibers. The percentage of fibers found was marked by the Image J® program and recorded in a Microsoft Excel spreadsheet. Statistical analysis was performed using SPSS (version 20), with a significance level of 95%. Results An increase in the collagen and elastic fibers sample was observed in the treated group. Morphometrically, a significant increase in the percentage of collagen in the Carboxytherapy group (41.44 ± 4.50%) was observed compared with the control group (37.44 ± 3.87%) with P = .04; for elastic fibers, the percentage showed no significant difference between the control group (10.55 ± 4.33%) and the carboxytherapy group (10.44 ± 3.71%). Conclusions Carboxytherapy with the parameters used in this study was able to stimulate collagen and elastic fiber synthesis, with significant differences in the morphometry for collagen fibers.

Section: Discussioncontrasting

confidence: 65%

Effects of carboxytherapy on skin laxity

Oliveira

Rocha

Cunha

et al. 2020

“…Skin photodamage is not only correlated with age, but also with sunbathing, which strongly accelerates this process. Similarly, there was no difference with regard to response results after an application of monopolar RF, between younger (below 45 years of age) and older (aged 30‐60 years) patients in the study by Tay and Kwok …”

Section: Discussionmentioning

confidence: 81%

The evaluation of elasticity after nonablative radiofrequency rejuvenation

Erkiert‐Polguj

Algiert-Zielińska

Zduńska

et al. 2018

Background: Laxity and rhytides are manifestations of photodamage on the face and chest. Nonablative radiofrequency (RF) is one of the most common procedures used for skin rejuvenation.Aim: The aim of this study was to assess the elasticity of face and chest skin after multipolar radiofrequency.Patients/Methods: Thirty women, aged 43-68, were included in the study. Twenty women were postmenopausal and 10 were premenopausal. They received 4 treatment sessions with an application of nonablative radiofrequency in 2-week intervals.Biomechanical properties of the skin were measured with the use of a Cutometer. Results:The objective evaluation in a cutometric analysis showed a statistically significant improvement between measurements taken in the pretreatment period and 3 months after the treatment. Conclusions:The study is an objective confirmation that RF treatment improves skin elasticity. The method may appear to be beneficial for women of any age and skin types. It is a noninvasive treatment with a low risk of complications. K E Y W O R D S chest rejuvenation, face rejuvenation, nonablative radiofrequency 1 | BACKGROUND Aging of the face, neck, and chest (décolletage) is a multifactorial process caused by the cumulative effects of intrinsic and environmental factors. It results in wrinkles, skin laxity, dyschromia, teleangiectasias, atrophy, and roughness of the epidermis. The growing demand to maintain a youthful appearance has led to an increase in the number of dermatological and surgical procedures aiming at delaying the process of skin aging. Advances in understanding skin biology have led to the development of many skin rejuvenation technologies, but there is an increased interest in nonablative treatment which tend to have minimal downtime and almost no complications. One such method is radiofrequency (RF). A RF device generates heat by transferring electrical energy, in the form of electromagnetic waves, from the electric field of the RF device to electrically charged particles in the tissue. 1 The heat leads to thermal damage of the collagen by breaking some cross-links, making the triple helix structure unwind. Some collagen fibers undergo denaturation, but then neocollagenesis occurs, increasing dermal thickness. Remodeling of collagen bundles and formation of new collagen lasts for months after the treatment. 2-6 Zelickson et al 2 showed increased expression of messenger RNA for collagen type 1 after RF treatment on abdomen skin. Kaplan and Gat 3 noted an induction of new collagen synthesis (focal thickening of collagen fibers) in skin biopsies done after the RF therapy. Several types of RF devices are available on the esthetic market.Among the most common are monopolar, bipolar, multipolar, and fractional bipolar ones. A monopolar RF device has only one active electrode, which remains in contact with the skin, and one grounding

“…The heated fibroblasts also activate new collagen formation. 29,30 The increase in collagen types I and III in the dermis occurs in a three-dimensional form, with continuity of up to three months after treatment, since the RFT current causes the positive regulation of certain sirtuin genes (SIRT), favoring the deposition of new collagen and also increasing the longevity of fibroblasts. 26 In addition to that, the body responds to elevation in temperature with the formation of a protein called heat shock protein (HSP).…”

Section: R Ad I Ofrequen C Y Ther Apy In the Tre Atment Of S K In L A...mentioning

confidence: 99%

“…Tissue retraction occurs due to the denaturation of the triple helix; because, when collagen is heated, the protein undergoes a transition from a highly organized crystalline structure to a random gel state. The heated fibroblasts also activate new collagen formation . The increase in collagen types I and III in the dermis occurs in a three‐dimensional form, with continuity of up to three months after treatment, since the RFT current causes the positive regulation of certain sirtuin genes (SIRT), favoring the deposition of new collagen and also increasing the longevity of fibroblasts .…”

Section: Radiofrequency Therapy In the Treatment Of Skin Laxity And M...mentioning

confidence: 99%

Radiofrequency therapy in esthetic dermatology: A review of clinical evidences

Bonjorno

Gomes

Pereira

et al. 2019

The skin is the largest human organ and is an important marker of chronological age. Throughout life, the body undergoes several changes caused by intrinsic and extrinsic factors that dictate the aging process. 1 With time, the skin becomes thinner and loses elasticity. The collagen fibrils gradually become more rigid, and there is a reduction in the number of elastic fibers and other components of the conjunctive tissue. 2 Such process happens to all individuals, boosting concerns about appearance with the marked increase in population's life expectancy.Novel technologies and techniques realized several cosmetic alternatives for minimizing the effects of human aging. [3][4][5][6] Noninvasive and minimally invasive procedures, such as radiofrequency, laser