A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

“…In this method, water soluble polymers, which assumes 5‐ to 20‐nm sizes in aqueous solutions, are utilized as they improve the water solubility of lipophilic drugs and improve their stability in blood 134–136 . A poly(2‐hydroxyethyl methacrylate) [poly(HEMA)] grafted lysine amino acid radiolabelled with such as 99m Tc has been applied for tumour diagnosis 137 . The nanobeads were radiolabelled by reacting eluent from a 99 Mo/ 99m Tc generator with the polymer prefunctionalized with magnetite in presence of SnCl 2 , as shown in Figure 5B.…”

“…(A) General strategies for radiolabelling of liposome by the passive encapsulation, remote labelling and membrane labelling approaches, dot circles denote radionuclides, reproduced from van der Geest et al, 126 and (B) scheme for functionalization of poly(2‐hydroxyethyl methacrylate) with l ‐lysine, which can be further used for radiolabelling with 99m Tc reproduced with permission from Appl Radiat Isot. (Elsevier, 2019) 137 …”