A novel, rapidly acquired and persistent spatial memory task that induces immediate early gene expression

Feldman, Lisa A.; Shapiro, Matthew L.; Nalbantoglu, Joséphine

doi:10.1186/1744-9081-6-35

Cited by 31 publications

(23 citation statements)

References 33 publications

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“…Our observations are consistent with prior reports of CPPinduced cognitive impairments (Larkin et al 2008;Niimi et al 2008;Feldman et al 2010;Velazquez-Zamora et al 2011) and LTP disruption in the hippocampus and prefrontal cortex (Brun et al 2001). Additionally, Davies et al (2013a) demonstrated that GluN2B receptors in medial prefrontal cortex were critical to OST performance.…”

Section: Discussionsupporting

confidence: 92%

“…The competitive NMDA-r antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), which has previously been shown to impair memory (Larkin et al 2008;Niimi et al 2008;Feldman et al 2010;Velazquez-Zamora et al 2011) and to block long-term potentiation (Brun et al 2001), has also been shown to impair span in a study using a variable trial adaptation of the OST. Davies et al (2013a) demonstrated that systemic administration of CPP or the GluN2B-selective antagonist Ro 25-6981 impaired span without affecting nonspecific performance measures, indicating that competitive NMDA-r antagonists produce effects selective to the OST, as well.…”

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confidence: 99%

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Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task

et al. 2016

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Developed as a tool to assess working memory capacity in rodents, the odor span task (OST) has significant potential to advance drug discovery in animal models of psychiatric disorders. Prior investigations indicate OST performance is impaired by systemic administration of N-methyl-D-aspartate receptor (NMDA-r) antagonists and is sensitive to cholinergic manipulations. The present study sought to determine whether an impairment in OST performance can be produced by systemic administration of the competitive NMDA-r antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; 3, 10, 17 mg/kg i.p.) in a unique dual-component variant of the OST, and whether this impairment is ameliorated by nicotine (0.75 mg/kg i.p.). Male Sprague-Dawley rats were trained to asymptotic level of performance on a 24-trial two-comparison incrementing nonmatching to sample OST. In addition, rats were administered a two-comparison olfactory reference memory (RM) task, which was integrated into the OST. The RM task provided an assessment of the effects of drug administration on global behavioral measures, long-term memory and motivation. Several measures of working memory (span, longest run, and accuracy) were dose dependently impaired by CPP without adversely affecting RM. Analysis of drug effects across trial blocks demonstrated a significant impairment of performance even at low memory loads, suggesting a CPP-induced deficit of olfactory short-term memory that is not load-dependent. Although nicotine did not ameliorate CPP-induced impairments in span or accuracy, it did block the impairment in longest run produced by the 10 mg/kg dose of CPP. Overall, our results indicate that performance in our 24 odor two-comparison OST is capacity dependent and that CPP impaired OST working, but not reference, memory.The odor span task, which was originally developed by Dudchenko et al. (2000), makes use of a primary sensory modality for rodents (olfaction) to assess the neurobiological and neuropharmacological basis of rodent memory. In the original procedure, rats were trained to dig in cups of sand, each mixed with a different household spice (e.g., basil or paprika), to retrieve buried food rewards. On each successive trial, a novel odor was presented, along with every odor that had been presented in preceding trials, but only responses to the novel odor were reinforced. To respond accurately on any given trial the rat needed to remember each stimulus it had encountered earlier in the session and withholds responses to these stimuli. Therefore, memory demands escalated over the course of the procedure as the number of odors the rat was required to remember increased. Dudchenko et al. (2000) demonstrated that performance in the task declined across trials, indicating that task accuracy was negatively impacted by increasing memory load. However, in this OST procedure, the number of comparisons presented on each successive trial increases in tandem with the number of stimuli to remember, confounding the relationship between accuracy and mem...

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task

et al. 2016

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“…Other protocols have involved much longer inter-trial intervals (8-75 min) to reportedly assess working memory in rats (Hoane et al, 2008; Sarihi et al, 2000). Some more recent protocols have suggested that shorter inter-trial intervals (10-15 sec) should be used to accurately assess working memory (Aultman and Moghaddam, 2001; Feldman et al, 2010; Vorhees and Williams, 2006). Shorter inter-trial intervals (10-20 sec) may provide more meaningful comparisons with the radial arm maze and with human data (Cowan, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of testosterone on spatial learning and memory in adult male rats

Spritzer

Daviau

Coneeny

et al. 2011

Hormones and Behavior

125

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A male advantage over females for spatial tasks has been well documented in both humans and rodents, but it remains unclear how the activational effects of testosterone influence spatial ability in males. In a series of experiments, we tested how injections of testosterone influenced the spatial working and reference memory of castrated male rats. In the eight-arm radial maze, testosterone injections (0.500 mg/rat) reduced the number of working memory errors during the early blocks of testing but had no effect on the number of reference memory errors relative to the castrated control group. In a reference memory version of the Morris water maze, injections of a wide range of testosterone doses (0.0625-1.000 mg/rat) reduced path lengths to the hidden platform, indicative of improved spatial learning. This improved learning was independent of testosterone dose, with all treatment groups showing better performance than the castrated control males. Furthermore, this effect was only observed when rats were given testosterone injections starting seven days prior to water maze testing and not when injections were given only on the testing days. We also observed that certain doses of testosterone (0.250 and 1.000 mg/rat) increased perseverative behavior in a reversal-learning task. Finally, testosterone did not have a clear effect on spatial working memory in the Morris water maze, although intermediate doses seemed to optimize performance. Overall, the results indicate that testosterone can have positive activational effects on spatial learning and memory, but the duration of testosterone replacement and the nature of the spatial task modify these effects.

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“…Encoding long-term memories requires more research into the range of times that can be used for spacing, the number of instructional repetitions, and identifying other protocols that induce LTP and LTM encoding. For example, LTP can be triggered in rats in very short spaces by alternating hidden and visual cues (Feldman et al, 2010), using 10 min spaces without stimuli (Morris, 2003; Fields, 2005), and spaces of an hour or more (Kramár et al, 2012). Evidence from other species (Jin et al, 2011) and recent LTP research cast further light on these issues (Redondo and Morris, 2011).…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Making long-term memories in minutes: a spaced learning pattern from memory research in education

Kelley¹,

Whatson²

2013

Front. Hum. Neurosci.

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Memory systems select from environmental stimuli those to encode permanently. Repeated stimuli separated by timed spaces without stimuli can initiate Long-Term Potentiation (LTP) and long-term memory (LTM) encoding. These processes occur in time scales of minutes, and have been demonstrated in many species. This study reports on using a specific timed pattern of three repeated stimuli separated by 10 min spaces drawn from both behavioral and laboratory studies of LTP and LTM encoding. A technique was developed based on this pattern to test whether encoding complex information into LTM in students was possible using the pattern within a very short time scale. In an educational context, stimuli were periods of highly compressed instruction, and spaces were created through 10 min distractor activities. Spaced Learning in this form was used as the only means of instruction for a national curriculum Biology course, and led to very rapid LTM encoding as measured by the high-stakes test for the course. Remarkably, learning at a greatly increased speed and in a pattern that included deliberate distraction produced significantly higher scores than random answers (p < 0.00001) and scores were not significantly different for experimental groups (one hour spaced learning) and control groups (four months teaching). Thus learning per hour of instruction, as measured by the test, was significantly higher for the spaced learning groups (p < 0.00001). In a third condition, spaced learning was used to replace the end of course review for one of two examinations. Results showed significantly higher outcomes for the course using spaced learning (p < 0.0005). The implications of these findings and further areas for research are briefly considered.

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A novel, rapidly acquired and persistent spatial memory task that induces immediate early gene expression

Cited by 31 publications

References 33 publications

Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task

Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task

Effects of testosterone on spatial learning and memory in adult male rats

Making long-term memories in minutes: a spaced learning pattern from memory research in education

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