A novel repair method for the treatment of acute Achilles tendon rupture with minimally invasive approach using button implant: A biomechanical study

Huri, Gazi; Biçer, Ömer Sunkar; Ozgozen, Levent; Uçar, Yurdanur; Garbis, Nickolas; Hyun, Yoon Suk

doi:10.1016/j.fas.2013.06.012

Cited by 14 publications

(5 citation statements)

References 58 publications

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“…Young's modulus of the LHB tendon, analyzed by Carpenter et al, 2005 [59], showed clear similarities with the results obtained for swine digital extensor tendon [16], and a small similarity was noticed with mouse PT [31], rat AT [47], rat PT [52], and dog infraspinatus [21]. The LHB's ultimate stress [59] showed similarity with results reported for rat AT [45,47,49], rat PT [50][51][52], rabbit PT [68], sheep AT [34], swine extensor tendon [56], swine digital extensor [16], and swine AT [58]. The ultimate strain results showed similarities with data for mouse PT [32], mouse AT [29], rat AT [47], rat PT [51,53], rat tail tendon [53], rabbit PT [3], sheep PT [37], swine extensor tendon [56], and horse SDFT [27].…”

Section: Discussion Of Results With Strain Rate In Mm/ssupporting

confidence: 69%

Mechanical Properties of Animal Tendons: A Review and Comparative Study for the Identification of the Most Suitable Human Tendon Surrogates

et al. 2022

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The mechanical response of a tendon to load is strictly related to its complex and highly organized hierarchical structure, which ranges from the nano- to macroscale. In a broader context, the mechanical properties of tendons during tensile tests are affected by several distinct factors, due in part to tendon nature (anatomical site, age, training, injury, etc.) but also depending on the experimental setup and settings. This work aimed to present a systematic review of the mechanical properties of tendons reported in the scientific literature by considering different anatomical regions in humans and several animal species (horse, cow, swine, sheep, rabbit, dog, rat, mouse, and foal). This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. The literature research was conducted via Google Scholar, PubMed, PicoPolito (Politecnico di Torino’s online catalogue), and Science Direct. Sixty studies were selected and analyzed. The structural and mechanical properties described in different animal species were reported and summarized in tables. Only the results from studies reporting the strain rate parameter were considered for the comparison with human tendons, as they were deemed more reliable. Our findings showed similarities between animal and human tendons that should be considered in biomechanical evaluation. An additional analysis of the effects of different strain rates showed the influence of this parameter.

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Section: Discussion Of Results With Strain Rate In Mm/ssupporting

confidence: 69%

Mechanical Properties of Animal Tendons: A Review and Comparative Study for the Identification of the Most Suitable Human Tendon Surrogates

et al. 2022

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“…Mice and rats are included due to their prevalent use as laboratory animals and availability of species-specific molecular tools 6 , 47 . Larger animals are used increasingly as translational models due to their more comparable tendon dimensions and biomechanics 23 , 48 – 50 . Horses present an attractive model of human tendinopathy since their superficial digital flexor tendon is a weight-bearing and energy-storing tendon analogous to the human Achilles tendon, which is similarly prone to naturally occuring tendon disease with high recurrence rates 9 , 51 , 52 .…”

Section: Introductionmentioning

confidence: 99%

Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon research

Oreff

Fenu

Vogl

et al. 2021

Sci Rep

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For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importance of inflammation in tendon disease, this study compared the cellular and molecular features of inflammation in tenocytes of humans and four common model species (mouse, rat, sheep, and horse). While mouse and rat tenocytes most closely equalled human tenocytes’ low proliferation capacity and the negligible effect of inflammation on proliferation, the wound closure speed of humans was best approximated by rats and horses. The overall gene expression of human tenocytes was most similar to mice under healthy, to horses under transient and to sheep under constant inflammatory conditions. Humans were best matched by mice and horses in their tendon marker and collagen expression, by horses in extracellular matrix remodelling genes, and by rats in inflammatory mediators. As no single animal model perfectly replicates the clinical condition and sufficiently emulates human tenocytes, fit-for-purpose selection of the model species for each specific research question and combination of data from multiple species will be essential to optimize translational predictive validity.

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“…Large animals, with more similar tendon dimensions and biomechanics [108], are suitable for studies focusing on mechanical repair, comparing surgical repair techniques such as single-row Mason-Allen stitch and double-row medial horizontal mattress stitch at time zero [109,110], and after tendon healing [111]. The large size, the reduced ability for suture retention due to a well-aligned tendon structure, and the occurrence of re-tears in a proportion of subjects, even when post-operative activity is limited by attaching a 6-inch softball under the foot of the operated limb [112], make it more suitable for evaluating repair strategies focusing on mechanical stability and efficacy.…”

Section: Animal Models Of Tendon/ligament Injurymentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies

Tennyson

Zhang

et al. 2021

Cells

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Tendon and ligament injury poses an increasingly large burden to society. This systematic review explores whether mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can facilitate tendon/ligament repair in vivo. On 26 May 2021, a systematic search was performed on PubMed, Web of Science, Cochrane Library, Embase, to identify all studies that utilised MSC-EVs for tendon/ligament healing. Studies administering EVs isolated from human or animal-derived MSCs into in vivo models of tendon/ligament injury were included. In vitro, ex vivo, and in silico studies were excluded, and studies without a control group were excluded. Out of 383 studies identified, 11 met the inclusion criteria. Data on isolation, the characterisation of MSCs and EVs, and the in vivo findings in in vivo models were extracted. All included studies reported better tendon/ligament repair following MSC-EV treatment, but not all found improvements in every parameter measured. Biomechanics, an important index for tendon/ligament repair, was reported by only eight studies, from which evidence linking biomechanical alterations to functional improvement was weak. Nevertheless, the studies in this review showcased the safety and efficacy of MSC-EV therapy for tendon/ligament healing, by attenuating the initial inflammatory response and accelerating tendon matrix regeneration, providing a basis for potential clinical use in tendon/ligament repair.

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A novel repair method for the treatment of acute Achilles tendon rupture with minimally invasive approach using button implant: A biomechanical study

Cited by 14 publications

References 58 publications

Mechanical Properties of Animal Tendons: A Review and Comparative Study for the Identification of the Most Suitable Human Tendon Surrogates

Mechanical Properties of Animal Tendons: A Review and Comparative Study for the Identification of the Most Suitable Human Tendon Surrogates

Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon research

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies

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