A Novel Retrovirus (Gunnison’s Prairie Dog Retrovirus) Associated With Thymic Lymphoma in Gunnison’s Prairie Dogs in Colorado, USA

Butler, Molly; Griffin, Karen A.; Brewster, Connie D.; Kapuscinski, Marylee; Stenglein, Mark D.; Tripp, Daniel W.; Quackenbush, Sandra L.; Fox, Karen A.

doi:10.3390/v12060606

Cited by 8 publications

(3 citation statements)

References 63 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, lesions were remarkably similar in distribution and severity, which could indicate a viral etiology. Oncogenic viruses, specifically those of the retroviral lineage, such as the Koala Retrovirus and Gunnison's Prairie Dog Retrovirus are associated with lymphoid neoplasia in wildlife in Australia and elsewhere [43,44]. As males were slightly overrepresented with lymphoid neoplasia in this study, it is less likely that a viral entity is involved although it might be worth exploring this hypothesis in future studies.…”

Section: Discussionmentioning

confidence: 69%

Spontaneous Pathology of Endangered Geriatric Julia Creek Dunnarts (<em>Sminthopsis douglasi</em>, Archer 1979) with Emphasis in Reproductive Pathology

Gonzalez-Astudillo,

Schaffer-White,

Noble

et al. 2024

Preprint

View full text Add to dashboard Cite

Julia Creek dunnarts are an endangered species of carnivorous marsupials and the focus of multiple conservation strategies involving significant resources such as captive breeding programs. Despite the relevance for conservation, no study to date has focused on evaluating geriatric diseases in dunnarts. This study describes the pathology findings in a group of 36 captive-born, mostly geriatric Julia Creek dunnarts that failed to produce offspring over multiple breeding periods. A total of 20 females and 16 males were submitted for a postmortem examination, with ages ranging from 9-42 and 12-42 months for females and males, respectively. Of these, 10 had unremarkable findings. The most common condition in females was cystic endometrial hyperplasia (n=7) and cystic ovaries (n=2), typical of hormonal dysregulation profiles in senescence, particularly hyperestrogenism. Rarely, cutaneous disease represented by unidentified dermal round cell infiltrates was observed in females (n=2). Primary reproductive hormonal dysregulation was also suspected in males diagnosed with testicular degeneration, necrosis and aspermatogenesis and/or atrophy (n=3). Cutaneous round cell infiltrates, possibly compatible with epitheliotropic lymphomas were more common in males (n=3), and 2/3 affected males also had concurrent testicular degeneration or necrosis, indi-cating male sex could be a predictor for lymphoid neoplasia in aged dunnarts especially in indi-viduals with concurrent testosterone-luteinizing hormone dysregulation as it occurs in gonadec-tomized animals. The role of an underlying viral etiology is also explored. This study is the first to describe major spontaneous diseases in endangered aged Julia Creek dunnarts, providing an im-portant understanding of senescence and geriatric diseases within a conservation context.

show abstract

Section: Discussionmentioning

confidence: 69%

Spontaneous Pathology of Endangered Geriatric Julia Creek Dunnarts (<em>Sminthopsis douglasi</em>, Archer 1979) with Emphasis in Reproductive Pathology

Gonzalez-Astudillo,

Schaffer-White,

Noble

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Interestingly, lesions were remarkably similar in distribution and severity, which could indicate a viral etiology. Oncogenic viruses, specifically those of the retroviral lineage, such as the Koala Retrovirus and Gunnison's Prairie Dog Retrovirus are associated with lymphoid neoplasia in wildlife in Australia and elsewhere [50,51]. This hypothesis might be worth exploring in future studies.…”

Section: Discussionmentioning

confidence: 98%

Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis douglasi, Archer 1979) with Emphasis in Reproductive Pathology

Gonzalez-Astudillo,

Schaffer-White,

Noble

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

Julia Creek dunnarts are an endangered species of carnivorous marsupials and the focus of multiple conservation strategies involving significant resources such as captive breeding programs. Despite the relevance for conservation, no study to date has focused on evaluating geriatric diseases in dunnarts. This study describes the pathology findings in a group of one wild and thirty-five captive-born, mostly geriatric Julia Creek dunnarts that failed to produce offspring over multiple breeding periods. A total of 20 females and 16 males were submitted for a postmortem examination, with ages ranging from 9 to 42 and 12 to 42 months for females and males, respectively. Of these, 10 had unremarkable findings. The most common condition in females was cystic glandular hyperplasia (n = 8), typical of hormonal dysregulation profiles in senescence, particularly hyperestrogenism. Rarely, cutaneous disease represented by unidentified dermal round cell infiltrates was observed in females (n = 2). Primary reproductive hormonal dysregulation was also suspected in males diagnosed with testicular degeneration, aspermatogenesis and/or atrophy (n = 3). Cutaneous round cell infiltrates, possibly compatible with epitheliotropic lymphomas, were seen in males (n = 3), and 2/3 affected males also had concurrent testicular degeneration or atrophy, indicating male sex could be a predictor for lymphoid neoplasia in aged dunnarts, especially in individuals with concurrent testosterone-luteinizing hormone dysregulation as it occurs in gonadectomized animals. The role of an underlying viral etiology is also explored. This study is the first to describe major spontaneous diseases in endangered aged Julia Creek dunnarts, providing an important understanding of senescence and geriatric diseases within a conservation context.

show abstract

“…Butler et al [12] successfully identified a novel type D beta-retrovirus Gunnison's prairie dog retrovirus (GPDRV) linked with three cases of thymic lymphoma, a type of blood cancer, in free-ranging Gunnison's prairie dogs. The authors demonstrated that infection with GPDRV can lead to developing thymic lymphoma in Gunnison's prairie dogs.…”

mentioning

confidence: 99%

Tumor Viruses and Their Associated Cancers: Remain on the Track with the Latest Advances

Hassan

2022

Viruses

View full text Add to dashboard Cite

show abstract

A Novel Retrovirus (Gunnison’s Prairie Dog Retrovirus) Associated With Thymic Lymphoma in Gunnison’s Prairie Dogs in Colorado, USA

Cited by 8 publications

References 63 publications

Spontaneous Pathology of Endangered Geriatric Julia Creek Dunnarts (<em>Sminthopsis douglasi</em>, Archer 1979) with Emphasis in Reproductive Pathology

Spontaneous Pathology of Endangered Geriatric Julia Creek Dunnarts (<em>Sminthopsis douglasi</em>, Archer 1979) with Emphasis in Reproductive Pathology

Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis douglasi, Archer 1979) with Emphasis in Reproductive Pathology

Tumor Viruses and Their Associated Cancers: Remain on the Track with the Latest Advances

Contact Info

Product

Resources

About