A novel role of long non-coding RNAs in response to X-ray irradiation

Nie, Jing; Peng, Chaojun; Pei, Weiwei; Zhu, Wei; Zhang, Shuyu; Cao, Han; Qi, Xiaofei; Tong, Jian; Jiao, Yang

doi:10.1016/j.tiv.2015.09.007

Cited by 21 publications

(17 citation statements)

References 45 publications

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“…The senescence-associated lncRNAs are differentially expressed in proliferating and senescent fibroblasts, as assessed by RNA sequencing [ 224 – 226 ]. Toxicological studies associate increased ROS production with increased expression of a set of 115 lncRNAs, which significantly affect p53 signaling pathway [ 227 ]. A mitochondrial-transcribed lncRNA is induced in aorta and endothelial cells aging, during the “replicative vascular senescence,” which is partly responsible for age-associated cardiovascular diseases, but not in the “stress-induced premature senescence” by ROS [ 228 ].…”

Section: Ros In Cell Senescencementioning

confidence: 99%

“…Cause-effect relationships between cell ROS production and cell senescence have been investigated through diverse pathways that include the field of mitochondrial DNA and autophagy inhibition and the effects of the microRNAs miR-210 and miR-494 in various mitochondrial processes [ 159 ]. These pathways highlight ROS contribution to prime cell senescence at diverse levels, among which epigenetic level is attracting more and more attention in studies aimed at the senescence control [ 227 , 233 , 236 ]. Indeed, the epigenetic modulation provides the essential and flexible interface between the organisms and the environment, which results in being essential for all the cell functions [ 122 , 123 , 129 ], throughout the lifespan [ 135 – 137 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

Davalli

Mitić

Caporali

et al. 2016

Oxidative Medicine and Cellular Longevity

811

579

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The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease. Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS) and/or Reactive Nitrosative Species (RNS). Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way. Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes. Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.

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Section: Ros In Cell Senescencementioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

Davalli

Mitić

Caporali

et al. 2016

Oxidative Medicine and Cellular Longevity

811

579

View full text Add to dashboard Cite

show abstract

“…The altered lncRNA-HOTAIR and MALAT1 expression might be involved in response to polycyclic aromatic hydrocarbons-induced DNA damage (Gao et al, 2016). Another study found that lncRNAs response to radiation-induced DNA damage and oxidative stress was involved in the p53 signaling pathway (Nie et al, 2015). This suggests that lncRNAs-Loc554202 was significantly increased compared with normal control in breast cancer tissues, and associated with advanced pathologic stage and tumor size (Shi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish ( Danio rerio ) using high-throughput sequencing

Wang

Lin

et al. 2017

Aquatic Toxicology

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Long non-coding RNAs (lncRNAs) have attracted considerable research interest, but so far no data are available on the roles of lncRNAs and their target genes under chronic β-diketone antibiotic (DKAs) exposure to zebrafish (Danio rerio). Herein, we identified 1.66, 3.07 and 3.36×10 unique lncRNAs from the 0, 6.25 and 12.5mg/L DKA treatment groups, respectively. In comparison with the control group, the 6.25 and 12.5mg/L treatments led to up-regulation of 2064 and 2479 lncRNAs, and down-regulation of 778 and 954 lncRNAs, respectively. Of these, 44 and 39 lncRNAs in the respective 6.25 and 12.5mg/L treatments displayed significant differential expression. Volcano and Venn diagrams of the differentially expressed lncRNAs were constructed on the basis of the differentially expressed lncRNAs. After analyzing 10 lncRNAs and potential target genes, a complex interaction network was constructed between them. The consistency of 7 target genes (tenm3, smarcc1b, myo9ab, ubr4, hoxb3a, mycbp2 and CR388046.3), co-regulated by 3 lncRNAs (TCONS_00129029, TCONS_00027240 and TCONS_00017790), was observed between their qRT-PCR and transcriptomic sequencing. By in situ hybridization (ISH), abnormal expression of 3 lncRNAs was observed in hepatic and spleen tissues, suggesting that they might be target organs for DKAs. A similar abnormal expression of two immune-related target genes (plk3 and syt10), co-regulated by the 3 identified lncRNAs, was observed in liver and spleen by ISH. Histopathological observations demonstrated hepatic parenchyma vacuolar degeneration and clot formation in hepatic tissues, and uneven distribution of brown metachromatic granules and larger nucleus in spleen tissues resulting from DKA exposure. Overall, DKA exposure led to abnormal expression of some lncRNAs and their potential target genes, and these genes might play a role in immune functions of zebrafish.

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“…These results are partially consistent with previous studies. For example, Nie et al found enrichment of genes involved in metabolism, the cell cycle and the DDR after X-ray irradiation [34]. Terradas et al reported that after high-dose irradiation, lncRNAs involved in the cell cycle, DNA repair, and the DDR were identified [35].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of the Altered lncRNAs and mRNAs Expression in 293T Cells after Ionizing Radiation Exposure

Sun

Xiao

et al. 2019

IJMS

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Tissue and cell damage caused by ionizing radiation is often highly genotoxic. The swift repair of DNA damage is crucial for the maintenance of genomic stability and normal cell fitness. Long noncoding RNAs (lncRNAs) have been reported to play an important role in many physiological and pathological processes in cells. However, the exact function of lncRNAs in radiation-induced DNA damage has yet to be elucidated. Therefore, this study aimed to analyze the potential role of lncRNAs in radiation-induced DNA damage. We examined the expression profiles of lncRNAs and mRNAs in 293T cells with or without 8 Gy irradiation using high-throughput RNA sequencing. We then performed comprehensive transcriptomic and bioinformatic analyses of these sequencing results. A total of 18,990 lncRNAs and 16,080 mRNAs were detected in all samples. At 24 h post irradiation, 49 lncRNAs and 323 mRNAs were differentially expressed between the irradiation group and the control group. qRT-PCR was used to verify the altered expression of six lncRNAs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that the predicted genes were mainly involved in the histone mRNA metabolic process and Wnt signaling pathways. This study may provide novel insights for the study of lncRNAs in radiation-induced DNA damage.

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A novel role of long non-coding RNAs in response to X-ray irradiation

Cited by 21 publications

References 45 publications

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish ( Danio rerio ) using high-throughput sequencing

Integrated Analysis of the Altered lncRNAs and mRNAs Expression in 293T Cells after Ionizing Radiation Exposure

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