A novel route for the synthesis of pseudopolyrotaxane containing γ-Cyclodextrin based on environmental waste recycling

Dardeer, Hemat M.; Toghan, Arafat

doi:10.1016/j.molstruc.2020.129707

Cited by 13 publications

(5 citation statements)

References 39 publications

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“…The shifting that occurs in absorbance bands could strongly illustrate the formation of an inclusion complex between PEG and the macrocyclic molecules of α-CDs. The enhancement in frequencies is due to the insertion of the PEG chain through the electron-rich cavity of the cyclodextrin rings [73][74][75][76]. In contrast, the decreasing in frequencies is due to the creation of van der Waals forces, hydrogen bonds between the adjacent α-CDs and the hydrogen bonds between the hydroxyl groups of α-CDs and the oxygen ether linkages in PEG.…”

Section: Ft-ir-studiesmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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Polymers and their composites have recently attracted attention in both pharmaceutical and biomedical applications. Polyethylene glycol (PEG) is a versatile polymer extensively used in medicine. Herein, three novel PEG-based polymers that are pseudopolyrotaxane (PEG/α-CD) (1), titania–nanocomposite (PEG/TiO2NPs) (2), and pseudopolyrotaxane–titania–nanocomposite (PEG/α-CD/TiO2NPs) (3), were synthesized and characterized. The chemical structure, surface morphology, and optical properties of the newly materials were examined by FT-IR, 1H-NMR, SEM, and UV–Vis., respectively. The prepared polymers were used as drug carriers of sulfaguanidine as PEG/α-CD/Drug (4), PEG/TiO2NPs/Drug (5), and PEG/α-CD/TiO2NPs/Drug (6). The influence of these drug-carrying formulations on the physical and chemical characteristics of sulfaguanidine including pharmacokinetic response, solubility, and tissue penetration was explored. Evaluation of the antibacterial and antibiofilm effect of sulfaguanidine was tested before and after loading onto the prepared polymers against some Gram-negative and positive bacteria (E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA)), as well. The results of this work turned out to be very promising as they confirmed that loading sulfaguanidine to the newly designed polymers not only showed superior antibacterial and antibiofilm efficacy compared to the pure drug, but also modified the properties of the sulfaguanidine drug itself.

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Section: Ft-ir-studiesmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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“…The absorption band at 1660 cm −1 is assigned to free C=O stretching vibration 55 . The absorption bands at 1560 and 1413 cm −1 corresponding to the polymer (C=N) group bending 56 and stretching vibration of (CH 2 –OH), were shifted towards higher wave numbers and decreased in their intensities, because of the interaction between the polymer blend chains and the ZnO NPs 57 . The band at 1073 cm −1 which is attributed to C–O–C stretching became less intense and was shifted to lower wavenumber.…”

Section: Resultsmentioning

confidence: 99%

One-pot synthesis of novel chitosan-salicylaldehyde polymer composites for ammonia sensing

Saeed,

Taha,

Dardeer

et al. 2024

Sci Rep

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Chitosan (Chs)-salicylaldehyde (Sal) polymer derivatives were formed via the reaction of Chs-Sal with zinc oxide nanoparticles (ZnO NPs) and beta-cyclodextrin (β-CD). These polymers were synthesized through inclusion with β-CD and doping with ZnO NPs to give pseudopolyrotaxane and Chs-Sal/ZnO NPs composite, respectively, for low-temperature detection and sensing of NH3 vapors as great significance in environmental control and human health. Additionally, the polymer (Chs-Sal/β-CD/ZnO NPs) was prepared via the insertion of generated composite (Chs-Sal/ZnO NPs) through β-cyclodextrin ring. The structural and morphological characterizations of the synthesized derivatives were confirmed by utilizing FTIR, XRD and, SEM, respectively. Also, the optical properties and thermal gravimetric analysis (TGA) of the synthesized polymers were explored. The obtained results confirmed that using β-CD or ZnO NPs for modification of polymer (Chs-Sal) dramatically enhanced thermal stability and optical features of the synthesized polymers. Investigations on the NH3-sensing properties of Chs-Sal/β-CD/ZnO NPs composite were carried out at concentrations down to 10 ppm and good response and recovery times (650 s and 350 s, respectively) at room temperature (RT) and indicated that modification by β-CD and doping with ZnO NPs effectively improves the NH3-sensing response of Chs-Sal from 712 to 6192 using Chs-Sal/β-CD/ZnO NPs, respectively, with low LOD and LOQ of 0.12 and 0.4 ppb, respectively.

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“…In addition, the bands for (PC6) appeared at 2854, 3018, 1736, and 1671, respectively, with increasing and decreasing intensity; this result is due to the overlapping between carbonyl groups with OH groups. Also, the hydrogen bond interaction between the carbonyl groups of the guest molecule and the (OH) groups of the β-CD ring causes the displacement of the C=C and carbonyl groups to higher wavenumbers and boosts their intensity [ 37 , 43 – 46 ]. Due to the inclusion of (CoP6) inside the hydrophobic cavity of β-CD, the distinctive absorption band due to (OH) groups of (PC6) became sharper than pure β-CD [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…These results could mean that (CoP5-7) and β-CD join together to make a complexation. The maximum value is raised by incorporating (CoP5-7) chains into the cyclodextrin rings' electron-rich cavity [ 37 , 43 ]. Instead, hydrogen bonding between neighboring β-CD rings and Vander Waals forces between the OH groups of β-CDs and CO groups of copolymers are responsible for the attenuation of peaks.…”

Section: Resultsmentioning

confidence: 99%

Modification of conducting arylidene copolymers by formation of inclusion complexes: synthesis, characterization, and applications as highly corrosion inhibitors for mild steel

et al. 2023

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Modifying the metal surface is one solution to the industry’s growing corrosion problem. Thus, via threading approach and insertion of copolymers (CoP5-7) containing polyarylidenes through the internal cavity beta-cyclodextrin β-CD, novel pseudopolyrotaxanes copolymers (PC5-7) are developed, resulting in mild steel corrosion inhibition. Inhibitors of corrosion based on β-CD molecules adsorb strongly to metal surfaces because of their many polar groups, adsorption centers, many linkages of side chains, and benzene rings. The corrosion inhibition efficiencies IE % statistics have been revised via the Tafel polarization method and Spectroscopy based on the electrochemical impedance (EIS), with PC7 achieving the highest 99.93% in 1.0 M H2SO4; they are mixed-type inhibitors. The chemical composition of the resulting PCs is determined with Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) is utilized to examine the morphological structure of the produced polymers, and X-ray diffraction is employed to identify crystallinity. Encapsulating CoP5-7 with β-CD changes the morphological structures and increases the generated PCs' crystallinity. The thermal stability of PCs is studied, indicating the presence of these CoPs within the β-CD cavities enhances their thermal stability. This research will be a stepping stone for developing high-efficiency anti-corrosion coatings and various industrial applications.

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A novel route for the synthesis of pseudopolyrotaxane containing γ-Cyclodextrin based on environmental waste recycling

Cited by 13 publications

References 39 publications

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

One-pot synthesis of novel chitosan-salicylaldehyde polymer composites for ammonia sensing

Modification of conducting arylidene copolymers by formation of inclusion complexes: synthesis, characterization, and applications as highly corrosion inhibitors for mild steel

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