A novel route in bone tissue engineering: Magnetic biomimetic scaffolds

Bock, Nathalie; Riminucci, Alberto; Dionigi, Chiara; Russo, Alessandro; Tampieri, Anna; Landi, Elena; Goranov, Vitaly; Marcacci, Maurilio; Dediu, V.

doi:10.1016/j.actbio.2009.09.017

Cited by 340 publications

(294 citation statements)

References 39 publications

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“…Computed tomography scanning was used to collect information and to maximize the visibility of the aneurysm's morphology and size, the angular relationship of the tumor with the aneurysm, the main source of the feeding artery, the tumor thrombus, and vessel wall calcification. This method also shows the relationship between the aneurysm anatomy and organ tissue, and it can improve the therapeutic effect (Bock et al, 2010). In this study, the CTA technique was used to detect the brain aneurysms, and the tumor resection was clearly visible.…”

Section: Discussionmentioning

confidence: 99%

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We sought to investigate the effect of nerve growth factor (NGF) expression on the formation and prognosis of cerebral aneurysms. Forty-eight cases were selected following a diagnosis of cerebral aneurysm using computed tomography angiography and surgical confirmation. Thirty-four cases of healthy deaths were also chosen. The tissue was tested for NGF expression changes by reverse-transcription PCR, Western blot and histopathology, and NGF expression was compared between the cerebral aneurysm and healthy groups. The expression level of NGF in cerebral aneurysm tissue was significantly increased over that observed in control tissue. The abnormal expression of NGF is related to cerebral aneurysms. The elevated expression of NGF in cerebral aneurysms may be associated with a poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis

et al. 2015

Genet. Mol. Res.

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“…Psychentonia, emotional excitement, strain, or vigorous head exercise could result in a sudden rise in the blood pressure, causing the aneurysm to rupture (Bock et al, 2010). In the present study, CTA was used to clearly locate cerebral aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm

et al. 2015

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ABSTRACT. We sought to investigate the relationship between abnormal expression of nitric oxide synthase (NOS) and pathogenesis of cerebral aneurysm. Brain tissues were collected from 36 patients with cerebral aneurysm confirmed by computer tomography with angiography or neurosurgical therapy. The control group consisted of 25 patients of similar age who had no vascular diseases, as confirmed by magnetic resonance imaging. Samples of cortical arterioles were collected. The structure of the aneurysms was detected by hematoxylin and eosin staining, and the expression of inducible NOS was detected by immunohistochemistry. NOS expression was significantly higher in the patient group than in the control group (patients: 30/36 strongly positive; control: 0/25 strongly positive; P < 0.05). In conclusion, the pathogenesis underlying cerebral aneurysm may be due to abnormal expression of NOS, degradation of the extracellular matrix, aggravation of a pro-inflammatory reaction, or a deficiency in arterial elasticity 4277 NOS and pathogenesis of cerebral aneurysm ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4276-4281 (2015) layer synthesis. These changes may result in a deficiency in vascular remodeling.

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“…The use of scaffolds in tissue engineering is constantly increasing, because these materials have become fundamental tools to help the body rebuild damaged or diseased tissues [1]. Of the scaffolds, the magnetic scaffold has attracted increasing attention because it can attract and take up angiogenic proteins such as growth factors (GFs) or other bio-agents such as stem cells in vivo via a driving magnetic force.…”

Section: Introductionmentioning

confidence: 99%

“…Of the scaffolds, the magnetic scaffold has attracted increasing attention because it can attract and take up angiogenic proteins such as growth factors (GFs) or other bio-agents such as stem cells in vivo via a driving magnetic force. This concept involves the use of magnetic nanoparticles (MNPs) which are functionalized with GFs or other bio-agents to be taken up by the magnetic scaffold [1]. These functionalized MNPs act as carriers transporting the bio-agents towards and inside the magnetic scaffold under the effect of a magnetic field [1].…”

Section: Introductionmentioning

confidence: 99%

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Visualization of Magnetic Nanofibers Using Magnetic Particle Imaging

Murase

Mimura²,

Banura³

et al. 2015

OJMI

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Purpose: Magnetic nanofibers (MNFs) are nanofibers impregnated with magnetic nanoparticles (MNPs). Magnetic particle imaging (MPI) is a recently introduced imaging method that allows imaging of the spatial distribution of MNPs. The purpose of this study was to develop MNFs and to investigate the feasibility of visualizing them using MPI and of heating them using an alternating magnetic field (AMF). Materials and Methods: First, chitosan nanofibers were cross-linked with glutaraldehyde vapor in a sealed vial for 24 hours. Next, they were mixed with various concentrations of MNPs and the mixture was stirred for 1 hour using a magnetic stirrer. After the mixture was refrigerated at -80˚C for 24 hours, it was freeze-dried for 24 hours. The morphology of the resultant MNFs was characterized by scanning electron microscopy, and the magnetic properties were measured using a vibrating sample magnetometer. After these measurements, we imaged the MNFs using our MPI scanner, and investigated the correlation between the pixel values of the MPI image and the concentration of MNPs or the number of MNF sheets. We also heated the MNFs using AMF, and measured the temperature rise using an infrared thermometer. Results: The MNFs were successfully visualized using our MPI scanner, and the pixel values of the MPI image showed excellent correlation with the concentration of MNPs (r = 0.992) and the number of MNF sheets (r = 0.997). A significant temperature rise was observed under AMF, and the initial slope of the time-dependent temperature rise showed excellent correlation with the concentration of MNPs (r = 0.994) and the number of MNF sheets (r = 0.979). Conclusion: The MNFs developed in this study can be visualized using MPI and can be applied to magnetic hyperthermia. They will be useful in biomedicine including cancer therapy and tissue regeneration.

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A novel route in bone tissue engineering: Magnetic biomimetic scaffolds

Cited by 340 publications

References 39 publications

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis

Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm

Visualization of Magnetic Nanofibers Using Magnetic Particle Imaging

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