“…119 Unfortunately, a lack of in vivo and in vitro data from scoliotic subjects means scoliotic models have only been validated against normal spine data. 79,105 Alternatively, studies have used models which have been previously validated 12,141,145,147 or developed a new scoliotic spine model using methods validated previously for creating healthy 77,78 or scoliotic spine models. 143,146 While it is not ideal to use a model in a context far from the one for which it was validated, in some cases this is unavoidable due to the lack of in vivo or in vitro data.…”