A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer

Zhang, Ke; Gao, Hui; Mo, Miao; Wu, Cai Jun; Hua, Yanqing; Chen, Zhen; Meng, Zhi Qiang; Liu, Lu Ming; Chen, Hao

doi:10.1016/j.pan.2018.12.010

Cited by 22 publications

(19 citation statements)

References 39 publications

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“…Mean platelet volume is another inflammatory marker, which has gained importance in patients with lung, pancreatic cancer . One of the key factors for VTE development is the platelet's contribution to the clot formation .…”

Section: Discussionmentioning

confidence: 99%

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

Farah

Nseir

Kagansky

et al. 2019

Clinical Laboratory Analysis

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Background: Acute venous thromboembolism (VTE) refers to deep venous thrombosis (DVT) of the extremities or pulmonary embolism (PE), or to both. Reliable imaging is not always available making a serologic diagnosis, or biomarker, highly desirable. Objective: This study aimed to examine the role of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) in detection patients with acute VTE. How to cite this article: Farah R, Nseir W, Kagansky D, Khamisy-farah R. The role of neutrophil-lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism.

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Section: Discussionmentioning

confidence: 99%

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

Farah

Nseir

Kagansky

et al. 2019

Clinical Laboratory Analysis

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“…25 A similar correlation was described in breast cancer or pancreatic cancer. 6,10,26 However, CLL is not the only type of cancer in which low MPV levels correlate with poor outcomes of the disease. In esophageal cancer, survival analysis revealed that both the diseasefree survival (DFS) and OS in the lower MPV group (MPV<7.4 fl) were significantly shorter than those in the high MPV group.…”

Section: Discussionmentioning

confidence: 99%

<p>Mean Platelet Volume Has Prognostic Value in Chronic Lymphocytic Leukemia</p>

Masternak

Puła

Knap

et al. 2020

CMAR

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Purpose: Mean platelet volume (MPV) is a readily accessible and commonly tested hematological indicator. Recent studies revealed a significant impact of MPV on the course and prognosis of many diseases, including some types of cancer, as well as on the incidence of atrial fibrillation and bleeding. The study aimed to perform a retrospective analysis of MPV in terms of time to first treatment (TTFT) and to determine its prognostic value in the group of patients with chronic lymphocytic leukemia (CLL). Moreover, the study includes a retrospective analysis of platelet parameters in patients treated with ibrutinib concerning bleeding and atrial fibrillation. Patients and Methods: The study included 523 patients with CLL, for 344 the most important cytogenetic aberrations were reported. The Mann-Whitney, Kruskal-Wallis, Kaplan-Meier, chi-squared, log-rank tests and multivariate Cox proportional hazard regression model were used to analyze collected data. Results: The receiver operating characteristic curve analysis was performed to identify optimal cutoff value for MPV. The analysis of survival curves showed that in the group of patients with higher values of MPV TTFT was significantly longer than in the group with lower MPV (17.9 vs 36 months, p=0.0015, cutoff value for MPV= 10.4 fl). In multivariate Cox proportional hazard regression model low MPV, the presence of del11q and del13q provided independent prognostic value for TTFT (HR=0.69, 95%-CI, 0.5293 to 0.9081; p=0.0078; HR=1.76, 95%-CI, 1.3000 to 2.3882, p=0.0003, HR=0.74, 95%-Cl, 0.5674 to 0.9588, p=0.0229, respectively). In the group treated with ibrutinib, 59 patients had no significant correlation between MPV level and the incidence of therapy complications, although in the group of patients with low MPV there was a tendency for more frequent occurrence of atrial fibrillation (p=0.259). Conclusion: Low MPV values are associated with unfavorable prognosis and might represent a novel, independent prognostic factor in CLL.

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“…Indeed, recent studies demonstrated a prognostic value of these parameters in different types of cancer. [32,33,34,35] Therefore, it is imperative that future studies address the significance of platelet parameters besides their counts in predicting postoperative outcomes. Data on MPV and PDW are not available in the NSQIP database.…”

Section: Discussionmentioning

confidence: 99%

Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study

Rachidi

Wallace

et al. 2019

Platelets

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Platelets play roles in malignancy, wound healing, and immunity. Nevertheless, their significance in postoperative outcomes is not established. This is a retrospective cohort study of 100,795 patients undergoing cancer surgery in 2010 and 2014 in >500 hospitals. Patients were stratified into five groups based on preoperative platelet counts.Multivariable logistic regression was used to determine the risk of 30-day mortality, morbidities, readmission, and prolonged hospitalization using the mid-normal group as a reference. We adjusted for demographic variables, comorbidities, and operation complexity. In the 2014 cohort, multivariable analysis showed that mortality was higher in patients with thrombocytopenia (OR 1.49, 95% CI [1.23-1.81]), high-normal platelets (OR 1.29, [1.06-1.55]), and thrombocytosis (OR 1.78, [1.45-2.19]). Composite postoperative morbidity followed a similar trend with thrombocytopenia (OR 1.34, [1.25-1.43]), high-normal counts (OR 1.41, [1.33-1.49]), and thrombocytosis (OR 2.20, [2.05-2.36]). Concordantly, the risks of prolonged hospitalization and 30-day readmission followed the same pattern. These results were validated in a large colon cancer cohort from the 2010 database. In conclusion, platelet count is a prognostic indicator in cancer surgeries. This could be related to the role of platelets in wound healing and immunity on one hand, and propagating malignancy on the other.

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A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer

Cited by 22 publications

References 39 publications

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

<p>Mean Platelet Volume Has Prognostic Value in Chronic Lymphocytic Leukemia</p>

Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study

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