Cholecystitis is a common disease with a high incidence, and attracts much attention. It not only harms human health, but also affects quality of work and life. Therefore, the choice of a suitable treatment is badly important for patients. In this paper, a novel selection model of treatments for cholecystitis based on hybrid multiple-criteria group decision-making (MCGDM), which is helpful to choose the most suitable treatment in the case of asymmetric information between doctors and patients. Subsequently, subjective and objective criteria are comprehensively taken into account in the index system of the selection model for cholecystitis, and combines 2-tuple linguistic with quantitative data analysis. Besides, the evaluation information obtained from the patient's conditions, the treatment and the hospital's medical status, etc., including real numbers, interval numbers, and linguistic labels with multi-granularity, is more complete and real. And the 2-tuple linguistic model is used to unify the non-homogeneous information, so the treatment selection is accurate and reliable. Simultaneously, for the unknown index and criteria weight, the improved entropy weight method and the BWM (best-worst-method) are utilized to figure out the index weight and criteria weight, respectively. Further, TODIM (an acronym in Portuguese for interactive and multicriteria decision-making model) method based on the prospect theory is applied to solve the prioritization of cholecystitis treatments, and give full consideration to the decision maker of risk aversion. Eventually, an empirical study of treatment selection for cholecystitis is conducted. Sensitivity analysis and comparative analysis indicate that the proposed selection model of treatments for cholecystitis patients is reliable and effective. INDEX TERMS Cholecystitis, best-worst method (BWM), entropy weight method, 2-tuple linguistic, group decision-making (MCGDM), TODIM.