A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO

Abstract

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembling of graphene oxide (GO) nanosheets and a NO donor BNN6 through the π-π stacking interaction. GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

Functionalized MoS2 Nanovehicle with Near‐Infrared Laser‐Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria‐Infected Wound Therapy

“…Synthesis of BNN6: N , N ′‐di‐sec‐butyl‐ N , N ′‐dinitroso‐1,4‐phenylenediamine (BNN6) was prepared according to a previously reported method . Typically, 6.0 m of sodium nitrite (20 mL) was added to 18 mL of 4.27 × 10 −3 m of BPA ethanol solution, while the mixed solution was stirred at room temperature under nitrogen for 30 min.…”

Light-Responsive Biodegradable Nanomedicine Overcomes Multidrug Resistance via NO-Enhanced Chemosensitization

“…The NO donor BNN6 is sensitive to UV–vis illumination for NO release. 28 The generated NO gas is able to break the nanoparticle shell and promote the release of wrapped DOX molecules, leading to a remarkable gas/drug effect that reverses MDR via NO-sensitized DOX efficacy enhancement (Figure 1). …”

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

“…Therefore, NO has been extensively explored in versatile biomedical applications such as cardiovascular homeostasis, bone metabolism and neurotransmission, respiratory diseases, antimicrobial therapy, wound healing, and antibacterial . Especially, NO can efficiently kill the cancer cells via the nitrosation of mitochondria and DNA, paving the new way for NO‐induced cancer therapy . In addition, it has been proved to enhance the therapeutic outcome of other therapeutic modalities such as PDT or RT, which indicates that NO‐based therapy can be developed either as the mainline therapeutic modality or as the assisted modality for enhancing other mainline therapeutic protocols .…”