A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway

Hussain, Safdar; Rafi, Kinza; Faizi, Shaheen; Razzak, Zaid Abdul; Simjee, Shabana Usman

doi:10.1007/s11010-018-3347-3

Cited by 6 publications

(9 citation statements)

References 38 publications

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“…The same group showed that enteric-coated nanoparticles of CD with intraperitoneal injection displayed more potently effective dosage with 0.16 mg/kgw/daily for a 10-day treatment period [43]. Hussain et al (2018) evaluated a semi-synthetic diterpenoid, 16(R&S) phenylaminocleroda-3,13(14)Z-dien-15,16 olide (derived from 16-oxocleroda-3,13(14)E-dien-15-oic acid (41), which could inhibit neuroblastoma SH-5Y5 cell proliferation through modulating the p53 pathway and apoptosis [113]. The IC 50 of this semi-synthetic compound is 12.5 µM for 48 h of treatment in SH-5Y5 cells, which could be comparative with cisplatin administration [113].…”

Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

“…Hussain et al (2018) evaluated a semi-synthetic diterpenoid, 16(R&S) phenylaminocleroda-3,13(14)Z-dien-15,16 olide (derived from 16-oxocleroda-3,13(14)E-dien-15-oic acid (41), which could inhibit neuroblastoma SH-5Y5 cell proliferation through modulating the p53 pathway and apoptosis [113]. The IC 50 of this semi-synthetic compound is 12.5 µM for 48 h of treatment in SH-5Y5 cells, which could be comparative with cisplatin administration [113]. Additionally, authors suggested that this agent did not affect the renal system in vivo, which could be considered for further cancer treatment.…”

Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

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Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

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Polyalthia belong to the Annonaceae family and are a type of evergreen tree distributed across many tropical and subtropical regions. Polyalthia species have been used long term as indigenous medicine to treat certain diseases, including fever, diabetes, infection, digestive disease, etc. Recent studies have demonstrated that not only crude extracts but also the isolated pure compounds exhibit various pharmacological activities, such as anti-oxidant, anti-microbial, anti-tumor, anti-cancer, etc. It is known that the initiation of cancer usually takes several years and is related to unhealthy lifestyle, as well as dietary and environmental factors, such as stress, toxins and smoking. In fact, natural or synthetic substances have been used as cancer chemoprevention to delay, impede, or even stop cancer growing. This review is an attempt to collect current available phytochemicals from Polyalthia species, which exhibit anti-cancer potentials for chemoprevention purposes, providing directions for further research on the interesting agents and possible clinical applications.

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Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

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“…Neuroblastoma (NB) is the most frequently diagnosed solid extracranial malignant tumor in the pediatric population and accounts for 15% of malignancy-related death in early childhood. , Treatment options remain limited for 60% of patients with high-risk NB . The failure to respond to chemotherapeutic regimens and distant organ dissemination is correlated with the presence of CSCs that are not effectively eliminated by conventional chemotherapies .…”

Section: Introductionmentioning

confidence: 99%

Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells

Wang

Zhou

et al. 2019

J. Am. Chem. Soc.

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The aim of this study is to illuminate a novel therapeutic approach by identifying a functional binding target of salinomycin, an emerging anticancer stem cell (CSC) agent, and to help dissect the underlying action mechanisms. By utilizing integrated strategies, we identify that nucleolin (NCL) is likely a salinomycin-binding target and a critical regulator involved in human neuroblastoma (NB) CSC activity. Salinomycin markedly suppresses NB CD34 expression and reduces CD34+ cell population in an NCL-dependent manner via disruption of the interaction of NCL with CD34 promoter. The elevated levels of NCL expression in NB tumors are associated with poor patient survival. Altogether, these results indicate that NCL is likely a novel functional salinomycin-binding target that exhibits the potential to be a prognostic marker for NB therapy.

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“…Terpenoids are the largest class of natural compounds and are known for their anticancer activity. ( Hussain et al, 2018 ), explored the anticancer effects of a novel semi-synthetic terpenoid, 16-oxo-cleroda-3,13 (14)E-diene-15-oic acid 1), derived from cleroda diterpene isolated from Polyalthia longifolia var. pendula against neuroblastoma ( Faizi et al, 2008 ).…”

Section: Semi-synthetic Studies For New Drugs Derived From Natural Co...mentioning

confidence: 99%

The use of African medicinal plants in cancer management

Gaobotse

Venkataraman²,

Brown³

et al. 2023

Front. Pharmacol.

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Cancer is the third leading cause of premature death in sub-Saharan Africa. Cervical cancer has the highest number of incidences in sub-Saharan Africa due to high HIV prevalence (70% of global cases) in African countries which is linked to increasing the risk of developing cervical cancer, and the continuous high risk of being infected with Human papillomavirus In 2020, the risk of dying from cancer amongst women was higher in Eastern Africa (11%) than it was in Northern America (7.4%). Plants continue to provide unlimited pharmacological bioactive compounds that are used to manage various illnesses, including cancer. By reviewing the literature, we provide an inventory of African plants with reported anticancer activity and evidence supporting their use in cancer management. In this review, we report 23 plants that have been used for cancer management in Africa, where the anticancer extracts are usually prepared from barks, fruits, leaves, roots, and stems of these plants. Extensive information is reported about the bioactive compounds present in these plants as well as their potential activities against various forms of cancer. However, information on the anticancer properties of other African medicinal plants is insufficient. Therefore, there is a need to isolate and evaluate the anticancer potential of bioactive compounds from other African medicinal plants. Further studies on these plants will allow the elucidation of their anticancer mechanisms of action and allow the identification of phytochemicals that are responsible for their anticancer properties. Overall, this review provides consolidated and extensive information not only on diverse medicinal plants of Africa but on the different types of cancer that these plants are used to manage and the diverse mechanisms and pathways that are involved during cancer alleviation.

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A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway

Cited by 6 publications

References 38 publications

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells

The use of African medicinal plants in cancer management

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