A novel series of phenolic temozolomide (TMZ) esters with 4 to 5-fold increased potency, compared to TMZ, against glioma cells irrespective of MGMT expression

Shervington, Leroy Alexander; Ingham, Oliver; Shervington, Amal

doi:10.1039/d0ra02686g

RSC Adv.

2020

DOI: 10.1039/d0ra02686g

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A novel series of phenolic temozolomide (TMZ) esters with 4 to 5-fold increased potency, compared to TMZ, against glioma cells irrespective of MGMT expression

Leroy Alexander Shervington

Oliver Ingham

Amal Shervington

Abstract: The standard of care treatment for patients diagnosed with glioblastoma multiforme (GBM) is temozolomide (TMZ).

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Cited by 5 publications

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et al. 2024

European Journal of Medicinal Chemistry Reports

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A novel series of phenolic temozolomide (TMZ) esters with 4 to 5-fold increased potency, compared to TMZ, against glioma cells irrespective of MGMT expression

Abstract: The standard of care treatment for patients diagnosed with glioblastoma multiforme (GBM) is temozolomide (TMZ).

Cited by 5 publications

References 27 publications

Combination of heme oxygenase-1 inhibitors and temozolomide to improve the anticancer effect in glioblastoma

Combination of heme oxygenase-1 inhibitors and temozolomide to improve the anticancer effect in glioblastoma

Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme

Electrochemical detection of genetic damage caused by the interaction of novel bifunctional anthraquinone-temozolomide antitumor hybrids with DNA modified electrode

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