The main cable and suspender of the spatial special-shaped suspension bridge are in the state of spatial stress; the structural stress is more complex than that of the parallel cable plane and finding the shape of the main cable of the spatial special-shaped cable plane is more difficult. In order to solve the problem of finding the shape of the main cable of the special-shaped suspension bridge, a new calculation model and algorithm of the main cable are proposed in this paper. The new calculation model adds constraints on the transverse bridge direction coordinates of the midspan on the basis of the original calculation model. The new calculation model can timely correct the calculation errors in all directions of the control node during the main cable shape finding process and improve the calculation accuracy. The new algorithm is a hybrid algorithm. The algorithm first uses the modified quantum genetic algorithm to solve and calculate the cable end force close to the real value, and then uses the cable end force obtained by the modified quantum genetic algorithm as the initial value to iterate through the modified least squares method. In this paper, a single cable plane curved suspension bridge is taken as the research background, and the differences of different calculation models in the shape-finding calculation of the main cable of the spatial special-shaped cable plane are compared. The results show that the proposed model is more stable in the calculation process, and the proposed algorithm has high accuracy and strong adaptability.