A novel simple biosensor containing silver nanoparticles/propolis (bee glue) for microRNA let-7a determination

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

“…This research highlighted that propolis-loaded NIMs induced more cytotoxic effect on HepG2 cells than HCT-116 cells, present three-fold higher therapeutic efficiency than free propolis and leads to the apoptosis of HepG2 cells, moreover, it increases propolis solubility with a controlling release profile in different gastrointestinal tract environments. On the same insight, and more recently, Elhakim et al [284] using a propolis sample from El Aliubiya region, constructed a sensitive electrochemical sensor containing silver nanoparticles/propolis for microRNAlet-7a detection and have been successfully tested on human serum samples, hepatocellular carcinoma patients and human liver cancer cells. This created biosensor could be used to largescale miRNAs detection [284] which may be involved in therapeutic application.…”

“…On the same insight, and more recently, Elhakim et al [284] using a propolis sample from El Aliubiya region, constructed a sensitive electrochemical sensor containing silver nanoparticles/propolis for microRNAlet-7a detection and have been successfully tested on human serum samples, hepatocellular carcinoma patients and human liver cancer cells. This created biosensor could be used to largescale miRNAs detection [284] which may be involved in therapeutic application. [284] On the other hand, propolis from Egypt, revealed a noteworthy capacity for the impairment of the antiinflammatory score and displayed a noticeable curative effect against biological disorder appeared in mouse conalbumin-induced asthma model.…”

“…This created biosensor could be used to largescale miRNAs detection [284] which may be involved in therapeutic application. [284] On the other hand, propolis from Egypt, revealed a noteworthy capacity for the impairment of the antiinflammatory score and displayed a noticeable curative effect against biological disorder appeared in mouse conalbumin-induced asthma model. [285] In addition, propolis from Egypt exhibited an antiparasitic capacity in animal model against tow human pathogenic parasite 'schistosomiasis and cryptosporidium'.…”

Co‐sensitized cells from Antarctic resources using Ag nanoparticles

“…[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Besides, silver nanoparticles (NPs) have been reported as useful to improve the performance with several goals, from biosensing to photovoltaic devices. [33][34][35] In particular, the use of dyes mixed with NPs for sensitization was reported as a successful way to increase DSSC performance. 36 Phycoerythrin is a red protein, with a maximum absorption band at 550 nm and a high molar absorption coefficient (10 6…”

“…Besides, silver nanoparticles (NPs) have been reported as useful to improve the performance with several goals, from biosensing to photovoltaic devices 33–35 . In particular, the use of dyes mixed with NPs for sensitization was reported as a successful way to increase DSSC performance 36 …”