2023
DOI: 10.1186/s13065-023-00951-0
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A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

Abstract: Atomoxetine (ATO) belongs to psychoanaleptic drugs and is utilized in attention-deficit hyperactivity syndrome treatment. In this study, two facile and selective approaches are implemented for the spectrophotometric analysis of atomoxetine. The two approaches rely on charge transfer formed between ATO base (n-donor) with p-chloranil and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ; π-acceptor). The generated complexes exhibit absorption intensity maxima at 550 and 460 nm in acetonitrile for p-chloranil and DDQ… Show more

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Cited by 4 publications
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“…Xanthene dyes like merbromin, eosin Y, fluorescein, and erythrosine B or 2,4,5,7‐tetraiodofluorescein (molecular weight = 879.86) have been recently utilized as spectrophotometric, spectrofluorimetric, and RRS probes for determining a wide range of active pharmaceutical ingredients such as atomoxetine daclatasvir, rupatadine, fluvoxamine, terbinafine, dapoxetine, cyclobenzaprine, duloxetine, asenapine, naftidrofuryl, and 𝛽‐blockers [23–34]. The remarkable fluorescence qualities and the high molar absorption coefficient of fluorescein parent molecules are attributed to their molecular geometry (planarity and rigidity) and their large conjugated system [35].…”
Section: Introductionmentioning
confidence: 99%
“…Xanthene dyes like merbromin, eosin Y, fluorescein, and erythrosine B or 2,4,5,7‐tetraiodofluorescein (molecular weight = 879.86) have been recently utilized as spectrophotometric, spectrofluorimetric, and RRS probes for determining a wide range of active pharmaceutical ingredients such as atomoxetine daclatasvir, rupatadine, fluvoxamine, terbinafine, dapoxetine, cyclobenzaprine, duloxetine, asenapine, naftidrofuryl, and 𝛽‐blockers [23–34]. The remarkable fluorescence qualities and the high molar absorption coefficient of fluorescein parent molecules are attributed to their molecular geometry (planarity and rigidity) and their large conjugated system [35].…”
Section: Introductionmentioning
confidence: 99%
“…Neither the fluorometric methodology nor the RRS methodology has yet been used for the quantitation of HXZ. The reaction ion pair formation between certain drugs (contain basic amine center) and erythrosin B or 2,4,5,7‐tetraiodofluorescein (TDF) has been widely utilized to determine a variety of active pharmaceutical ingredients such as terbinafine, rupatadine, dapoxetine naftidrofuryl, duloxetine, amlodipine, perindopril, atomoxetine, fluvoxamine, and venlafaxine by applying either spectrofluorimetric technique or RRS technique [16–24]. Furthermore, TDF possesses advantageous characteristics in terms of its cost‐effectiveness and long‐term stability.…”
Section: Introductionmentioning
confidence: 99%