Ejectors used in refrigeration systems as entrainment and compression components or expanders, alone or in combination with other equipment devices, have gained renewed interest from the scientific community as a means of low temperature heat recovery and more efficient energy use. This paper summarizes the main findings and trends, in the area of heat-driven ejectors and ejector-based machines, using low boiling point working fluids, which were reported in the literature for a number of promising applications. An overall view of such systems is provided by discussing the ejector physics principles, as well as a review of the main developments in ejectors over the last few years. Recent achievements on thermally activated ejectors for single-phase compressible fluids are the main focus in this part of the review. Aspects related to their design, operation, theoretical and experimental approaches employed, analysis of the complex interacting phenomena taking place within the device, and performance are highlighted. Conventional and improved ejector refrigeration cycles are discussed. Some cycles of interest employing ejectors alone or boosted combinations are presented and their potential applications are indicated.