A novel sterically mediated transformation of proline

Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1,3‐Oxazines

“…[16] Justifiably, the intrinsic versatility and synthetic utility of these heterocyclic systems has attracted great interest from chemists, who have developed several exquisite methods for their synthesis. [17] However, except for a few examples, [18] most of the reported strategies are primarily based on Mannich type condensations, which are restricted to the use of aliphatic alicyclic primary amines. Hence, regardless of these advances, investigations in search of more efficient routes for the synthesis of these compounds are still highly desirable for drug discovery and medicinal chemistry.…”

Classical-Reaction-Driven Stereo- and Regioselective C(sp3)-H Functionalization of Aliphatic Amines

“…1). [10] Our studies were initiated with the hope that similar transformations providing oxazine could be achieved by employing any secondary amine without pre-functionalization. Unfortunately, initial attempts to obtain the corresponding oxazine 57 starting from salicylaldehyde and pyrrolidine failed (Scheme 8).…”

“…[10] Further developments on this strategy have been reviewed on different occasions. [2] In this account, recent contributions from our group on direct a-and b-C(sp 3 )-H functionalization of aliphatic amines employing the classical CIA strategy are reviewed.…”

Metal–free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β‐Carboline N‐fused Imidazoles

“…[10] Further, a-amino acids/ esters are considered as the first choice for generation UPDATES DOI: 10.1002/adsc.201600970 of reactive azomethine ylides. [11] Recently, several research groups have extensively explored a-amino acids for construction of CÀC, CÀO and CÀN bond via intermediacy of azomethine ylides, however, Wang group have done the seminal contribution in this field. [12] Similarly, few metal assisted approaches have been developed for oxidative amination of benzyl amines with carbaldehydes for the synthesis of azomethine ylides.…”