Metabolic competence in conjunction with well-balanced nutritional support is extremely important for normal biochemical and physiological functions, as well as for enhanced athletic performance. Research-affirmed nutraceuticals enriched in structurally diverse phytonutrients including bioflavonoids may help to boost athletic, functional, and biophysiological competence. Occurrence of chronic degenerative disorders is associated with an increase in anaerobic events, namely, the inability to effectively use oxygen and water, and inability to use nutrients for cellular energy production and management, metabolic homeostasis, and waste removal. Earlier clinical studies in our laboratories using the WADA compliant bioflavonoid-enriched Prodosomed VMP35 Multinutrient Complex (“Prodovite®”) demonstrated that it boosted aerobic metabolic competence and provided protection against diverse chronic degenerative anaerobic disorders. We hypothesized that Prodosomed VMP35 may serve as a novel supplement to boost athletic performance. The objective of the study was to conduct selected focused pilot studies to demonstrate the efficacy of a WADA compliant Prodosomed VMP35 to improve athletic competence and performance in a variety of sports activities. The efficacy of VMP35 was assessed in different models of sports performance/athletic competence including power lifting, resistance training, cycling, and selected case studies. VMP35 supplementation restored aerobic metabolic events, minimized oxidative stress, and improved athletic performance, recovery, and immune competence. These pilot clinical studies demonstrate that iron-free VMP35 restores aerobic metabolism by restoring iron-dependent hemoglobin to red blood cells, bolstering neutrophils in the blood (immune support), and significantly improving performance output in a diverse range of athletic activities.