A novel structure of silver polymer through Na–O bonds with cytotoxicity property

Liu, Zhao‐Di; Zhang, You; Zhu, Hai‐Liang; Tan, Min‐Yu

doi:10.1016/j.inoche.2004.10.005

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…The antiproliferative effects using MTT assay in HCT-116 cells after 72 h exposure to the imidazolium salts (7-10) and silver complexes (11)(12)(13)(14) were evaluated according to an established procedure [19]. For the experiments, the compounds (100 μL) were prepared freshly as stock solutions in DMSO and diluted with the HCT 116 cell culture medium to the final assay concentrations (0.1% V/V DMF).…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Reactions involved in the syntheses of NHC precursors (7-10) and their respective Ag(I) bis-carbene complexes (11)(12)(13)(14) are summarized in Schemes 1 and 2, respectively. Bis-imidazoles with ortho-, metaand para-xylene cores [15] reacted with allyl bromide (2 equivalents) in acetonitrile to afford respective bis-imidazolium bromide salts as thick brown oils in good yield.…”

Section: Synthesesmentioning

confidence: 99%

“…In the complex cation, the Ag(I) is coordinated by Scheme 2. Synthetic pathway to Ag(I)-bis-carbene complexes (11)(12)(13)(14) from NHC precursors (7-10). (15) and 103.63(15) Å for N1-C6-N2 and N3-C18-N4, respectively, which are in well agreement with the reported complexes containing similar ligand architecture [26][27][28].…”

Section: Crystal Structuresmentioning

confidence: 99%

“…Therefore, the organometallic silver derivatives historically used to maintain human health, and also many silver salts are being used in healing the wounds to prevent infection [10]. However, literature survey revealed that the Ag(I)-carbene complexes derived from benzimidazole derivatives showed remarkably high activity against the human cancer cell line OVCAR-3 (ovarian), human renal cancer cell line (Caki-1), MB157 (breast) and HeLa (cervical) cell line [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies

Haque

Ghdhayeb

Salman

et al. 2012

Inorganic Chemistry Communications

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Section: Anticancer Activitymentioning

confidence: 99%

Section: Synthesesmentioning

confidence: 99%

Section: Crystal Structuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies

Haque

Ghdhayeb

Salman

et al. 2012

Inorganic Chemistry Communications

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Synthesis, cytotoxicity and antibacterial studies of symmetrically and non‐symmetrically benzyl‐ or p‐cyanobenzyl‐substituted N‐Heterocyclic carbene–silver complexes

Patil¹,

Deally²,

Gleeson³

et al. 2010

Applied Organom Chemis

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From the reaction of 1H-imidazole (1a), 4,5-dichloro-1H-imidazole (1b) and 1H-benzimidazole (1c) with p-cyanobenzyl (8b) and (1-methyl-3-benzylbenzimidazole-2-ylidene) silver(I) acetate (8c) respectively. The four NHC-precursors 3a-c, 7c and four NHC-silver complexes 4a-c and 8c were characterized by single crystal X-ray diffraction. The preliminary antibacterial activity of all the compounds was studied against Gram-negative bacteria Escherichia coli, and Gram-positive bacteria Staphylococcus aureus using the qualitative Kirby-Bauer disc-diffusion method. All NHC-silver complexes exhibited medium to high antibacterial activity with areas of clearance ranging from 4 to 12 mm at the highest amount used, while the NHC-precursors showed significantly lower activity. In addition, all NHC-silver complexes underwent preliminary cytotoxicity tests on the human renal-cancer cell line Caki-1 and showed medium to high cytotoxicity with IC 50 values ranging from 53 (±8) to 3.2 (±0.6) µM.

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Novel Benzyl‐ or 4‐Cyanobenzyl‐Substituted N‐Heterocyclic (Bromo)(carbene)silver(I) and (Carbene)(chloro)gold(I) Complexes: Synthesis and Preliminary Cytotoxicity Studies

Patil

Deally

Hackenberg

et al. 2011

Helvetica Chimica Acta

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N-Heterocyclic carbene (NHC) complexes bromo(1,3-dibenzyl-1,3-dihydro-2H-imidazol-2-ylidene)silver(I) (2a), bromo[1-(4-cyanobenzyl)-3-methyl-1,3-dihydro-2H-imidazol-2-ylidene]silver(I) (2b), and bromo[1-(4-cyanobenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-ylidene]silver(I) (2c) were prepared by the reaction of 1,3-dibenzyl-1H-imidazol-3-ium bromide (1a), 3-(4-cyanobenzyl)-1-methyl-1H-imidazol-3-ium bromide (1b), and 3-(4-cyanobenzyl)-1-methyl-1H-benzimidazol-3-ium bromide (1c), respectively, with silver(I) oxide. NHC Complexes chloro(1,3-dibenzyl-1,3-dihydro-2H-imidazol-2-ylidene)gold(I) (3a), chloro[1-(4-cyanobenzyl)-3-methyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(I) (3b), and chloro[1-(4-cyanobenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-ylidene]gold(I) (3c) were prepared via transmetallation of corresponding (bromo)(NHC)silver(I) complexes with chloro(dimethylsulfido)gold(I). The complex 3a was characterized in two polymorphic forms by single-crystal X-ray diffraction showing two rotamers in the solid state. The cytotoxicities of all three bromo(NHC)silver(I) complexes and three (chloro)(NHC)gold(I) complexes were investigated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bormide (MTT)-based preliminary in vitro testing on the Caki-1 cell line in order to determine their IC 50 values. (Bromo)(NHC)silver(I) complexes 2a -2c and (chloro)(NHC)gold(I) complexes 3a -3c were found to have IC 50 values of 27 AE 2, 28 AE 2, 34 AE 6, 10 AE 1, 12 AE 5, and 12 AE 3 mm, respectively, on the Caki-1 cell line.

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A novel structure of silver polymer through Na–O bonds with cytotoxicity property

Cited by 11 publications

References 11 publications

Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies

Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies

Synthesis, cytotoxicity and antibacterial studies of symmetrically and non‐symmetrically benzyl‐ or p‐cyanobenzyl‐substituted N‐Heterocyclic carbene–silver complexes

Novel Benzyl‐ or 4‐Cyanobenzyl‐Substituted N‐Heterocyclic (Bromo)(carbene)silver(I) and (Carbene)(chloro)gold(I) Complexes: Synthesis and Preliminary Cytotoxicity Studies

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