2023
DOI: 10.3390/cancers15061655
|View full text |Cite
|
Sign up to set email alerts
|

A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment

Abstract: Purpose: Identification of molecularly-defined cancer subgroups and targeting tumor-specific vulnerabilities have a strong potential to improve treatment response and patient outcomes but remain an unmet challenge of high clinical relevance, especially in head and neck squamous cell carcinoma (HNSC). Experimental design: We established a UCHL1-related gene set to identify and molecularly characterize a UCHL1-related subgroup within TCGA-HNSC by integrative analysis of multi-omics data. An extreme gradient boos… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 33 publications
0
0
0
Order By: Relevance
“…This study was conducted in accordance with the Declaration of Helsinki. IHC staining was performed in accordance with Burkart et al [ 31 ] using an anti-GAP43 antibody (ab75810, Abcam, Cambridge, UK). IHC-stained slides were scanned with a VENTANA DP 200 slide scanner (Roche, Mannheim, Germany), and to quantify the amount of GAP43-positive neuronal structures, the number of positive areas out of 10 was manually calculated.…”
Section: Methodsmentioning
confidence: 99%
“…This study was conducted in accordance with the Declaration of Helsinki. IHC staining was performed in accordance with Burkart et al [ 31 ] using an anti-GAP43 antibody (ab75810, Abcam, Cambridge, UK). IHC-stained slides were scanned with a VENTANA DP 200 slide scanner (Roche, Mannheim, Germany), and to quantify the amount of GAP43-positive neuronal structures, the number of positive areas out of 10 was manually calculated.…”
Section: Methodsmentioning
confidence: 99%